NONINVASIVE LOCALIZED IN VIVO BLOOD OXIMETRY USING MRI

描述（改编自申请人摘要）： 竞争性更新旨在继续开发和验证MR 血氧测定技术用于先天性心脏病的非侵入性评估。 将分三个阶段实现拟议目标。 首先，他们建议 进行初步临床研究，以确定MR血氧饱和度， 简单的修改，已经可以回答重大的临床问题， 对于有稳定的心脏缺陷的合作患者的问题 血流动力学，典型的房间隔缺损。 第二阶段将 解决在合作患者中执行MR测量的问题 具有不利的流动特性，例如高流量射流。 第三阶段 将先前开发的技术应用于婴儿 而儿童的解剖结构较小，心率较快， 合作能力下降。 在每一个阶段，从技术上讲， 需要在测量过程中取得具有挑战性的进展， 逐步发展。 这次调查的结果 大大加强对儿童和青少年的管理， 先天性心脏病，同时扩展MR血氧饱和度的一般用途。

DESCRIPTION (Adapted from Applicant's Abstract): This re-submission for a competitive renewal aims towards continuing to develop and verify MR oximetry techniques for noninvasive assessment of congenital heart disease. The proposed goal will be approached in three stages. First, they propose to perform an initial clinical study to establish that MR oximetry, with straightforward modifications, can already answer significant clinical questions for cooperative patients who have heart defects with stable hemodynamics, typically atrial septal defects. The second stage will address the problem of performing MR measurements in cooperative patients with adverse flow characteristics such as high flow jets. The third stage extends the application of the previously developed techniques to infants and children where the anatomy is smaller, heart rates are faster, and the ability to cooperate is reduced. At each stage, technically more challenging advances in the measurement process will be required and developed progressively. The results of this investigation will significantly enhance the management of children and young adults with congenital heart disease while extending the general utility of MR oximetry.