ORAL CAVITY IN AIDS--REGULATION/FUNCTION OF IGA

艾滋病口腔疾病--IGA 的调节/功能

• 批准号: 2458667
• 负责人: SUSAN JACKSON
• 金额: $ 27.75万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2458667
• 关键词: AIDS; B lymphocyte; HIV infections; RNase protection assay; T lymphocyte; antiviral antibody; clinical research; cytokine; cytotoxicity; enzyme linked immunosorbent assay; gene expression; human immunodeficiency virus; human subject; immunoglobulin A; intracellular; mucosal immunity; neutralizing antibody; oral mucosa; polymerase chain reaction; protein structure function; salivary glands; secretion; tissue /cell culture; virus replication

DESCRIPTION: Description (Adapted from Investigators Abstract): Saliva is normally inhibitory for HIV replication. One of the factors which may be involved in this is the primary defense factor in the oral cavity, namely secretory IgA. IgA is transported into secretions by secretory component (SC) synthesized by epithelial cells in the salivary glands. The expression of SC is regulated by cytokines. Since HIV infection has a profound effect on the immune system, the properties of salivary IgA antibodies of HIV infected patients will be examined including their specificity structure and function. Secondly, investigations will be initiated on the alterations of salivary cytokines or on cytokine expression by cells of the oral cavity which may influence oral manifestation of HIV infection. Third, the potential for intracellular formation of IgA anti-HIV/HIV complexes will be examined, which could lead to virus neutralization within epithelial cells in the oral cavity.

描述：描述(改编自调查人员摘要)：唾液是 通常抑制艾滋病毒复制。其中一个因素可能是 参与这一过程的是口腔中的主要防御因素，即 分泌型IgA。免疫球蛋白通过分泌成分转运到分泌物中 (SC)由唾液腺中的上皮细胞合成。表达方式 SC的表达受细胞因子调控。由于艾滋病毒感染具有深远的影响 在免疫系统中，HIV唾液IgA抗体的特性 将对感染患者进行检查，包括他们的特异性结构和 功能。第二，当局会展开调查更改 唾液细胞因子或口腔细胞因子表达的影响 这可能会影响HIV感染的口腔表现。第三， 细胞内形成IgA抗HIV/HIV复合体的可能性将是 检查，这可能导致上皮细胞内的病毒中和 在口腔里。