ORAL CAVITY IN AIDS--REGULATION/FUNCTION OF IGA

艾滋病口腔疾病--IGA 的调节/功能

• 批准号: 2749372
• 负责人: SUSAN JACKSON
• 金额: $ 28.86万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2749372
• 关键词: AIDS; B lymphocyte; HIV infections; RNase protection assay; T lymphocyte; antiviral antibody; clinical research; cytokine; cytotoxicity; enzyme linked immunosorbent assay; gene expression; human immunodeficiency virus; human subject; immunoglobulin A; intracellular; mucosal immunity; neutralizing antibody; oral mucosa; polymerase chain reaction; protein structure function; salivary glands; secretion; tissue /cell culture; virus replication

DESCRIPTION: Description (Adapted from Investigators Abstract): Saliva is normally inhibitory for HIV replication. One of the factors which may be involved in this is the primary defense factor in the oral cavity, namely secretory IgA. IgA is transported into secretions by secretory component (SC) synthesized by epithelial cells in the salivary glands. The expression of SC is regulated by cytokines. Since HIV infection has a profound effect on the immune system, the properties of salivary IgA antibodies of HIV infected patients will be examined including their specificity structure and function. Secondly, investigations will be initiated on the alterations of salivary cytokines or on cytokine expression by cells of the oral cavity which may influence oral manifestation of HIV infection. Third, the potential for intracellular formation of IgA anti-HIV/HIV complexes will be examined, which could lead to virus neutralization within epithelial cells in the oral cavity.

描述：描述（改编自研究者摘要）：唾液 通常抑制HIV复制。 其中一个因素可能是 参与其中的是口腔中的主要防御因素，即 分泌型伊加。 伊加通过分泌成分转运到分泌物中 (SC)由唾液腺上皮细胞合成。 表达 SC的表达受细胞因子的调节。 由于艾滋病病毒感染对人类 对免疫系统的影响，唾液中HIV伊加抗体的性质 将检查受感染的患者，包括其特异性结构， 功能 第二，将开始调查 唾液细胞因子或口腔细胞的细胞因子表达 这可能会影响艾滋病毒感染的口腔表现。 三是 伊加抗HIV/HIV复合物的细胞内形成的潜力将是 检查，这可能导致上皮细胞内的病毒中和 在口腔中。