EPIDEMIOLOGY OF HIV 1 AND HIV 2 ASSOCIATED ORAL DISEASE

HIV 1 和 HIV 2 相关口腔疾病的流行病学

• 批准号: 2545667
• 负责人: CATHY W CRITCHLOW
• 金额: $ 27.14万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2545667
• 关键词: Africa; disease /disorder proneness /risk; epidemiology; human immunodeficiency virus 1; human immunodeficiency virus 2; human subject; oral pharyngeal disorder

DESCRIPTION: This application proposes a study of the epidemiology of oral lesions among heterosexual women and men in Senegal, West Africa, who may be infected with either HIV-1, HIV-2, both HIV-1 and HIV-2, or who are HIV seronegative. Oral lesions are reported to develop among a substantial number of HIV infected individuals, and because incidence of HIV infection is greater in developing countries, a large percentage of those patients with HIV associated oral lesions will come from these settings. However, few systematic studies of the epidemiology of HIV associated oral disease in these populations have been undertaken. Many have reported on oral lesions among HIV-1 infected men, but many fewer data are available from women. Although AIDS is associated with HIV-2, as well as with HIV-1, in many West African countries, no published data is available concerning the risk of oral pathology associated with HIV-2. Comparative studies of oral lesions among those with HIV-1, HIV-2, or both HIV types, taking into account other potential risk factors for these lesions, are of particular interest because of the slower rate of immune function decline seen with HIV-2 as compared with HIV-1. Little is known about the frequency with which HIV-1 or HIV-2 can be detected within the oral cavity. Defining risk and predictors of oral HIV-1 and HIV-2 DNA/RNA may be important with respect to implications for our increased understanding of the natural history of HIV infection and potentially of HIV transmission. Correlation of the presence and quantity of oral HIV with HIV in the peripheral blood, CD4 count, and demographic characteristics, may provide insights into potential observed differences. This application proposes to address these issues using the infrastructure which has been developed in Senegal conducting cross-sectional (R01CA50856) and now cohort (R01CA46823) studies of HIV and neoplasia. The investigators plan to recruit women enrolling in that study, as well as to recruit men presenting to the same study clinic. The extensive data already being collected from the women participating in this other cohort study will be available to the proposed study. Specifically among cohorts of women and men with HIV-1, HIV-2, or both HIV-1 and HIV-2, and among HIV seronegative subjects, the investigators propose to: (1) describe the prevalence and nature of oral lesions associated with each HIV type; and (2) compare the quantity of detectable HIV DNA/RNA in the oral cavity with respect to the infecting HIV type and risk factors for its detection.

描述：此应用程序提出了一项流行病学研究 西塞内加尔异性恋女性和男性口腔损害的研究 非洲，可能感染艾滋病毒-1、艾滋病毒-2、艾滋病毒-1和艾滋病毒-2 HIV-2，或HIV血清阴性者。口腔损伤被报告给 在相当数量的艾滋病毒感染者中发展，以及 由于艾滋病毒感染在发展中国家的发病率较高， 很大比例的HIV相关口腔患者 损伤将来自这些环境。然而，很少有系统的 HIV相关口腔疾病的流行病学研究 已经进行了人口普查。许多人已经报道了口腔损伤 在感染HIV-1的男性中，但从 女人。尽管艾滋病与艾滋病毒-2以及 HIV-1，在许多西非国家，没有公布的数据 关于与艾滋病毒-2相关的口腔病理风险。 HIV-1、HIV-2、HIV-2感染者口腔病变的比较研究 或两种类型的艾滋病毒，考虑到其他潜在的风险因素 对于这些病变，尤其值得关注，因为速度较慢 与HIV-1相比，HIV-2免疫功能下降的比率。 人们对HIV-1或HIV-2感染的频率知之甚少 在口腔内检测到。定义口腔疾病的风险和预测因素 HIV-1和HIV-2DNA/RNA在以下方面可能很重要 对我们加深对自然环境的理解的启示 艾滋病毒感染史和潜在的艾滋病毒传播史。 口服液中HIV的存在和数量与HIV的相关性 外周血、CD4计数和人口统计学特征，可能 提供对潜在观察到的差异的洞察。这 应用程序建议使用基础设施来解决这些问题 它已经在塞内加尔开发，进行横截面 (R01CA50856)和现在的队列(R01CA46823)关于艾滋病毒和肿瘤的研究。 调查人员计划招募女性参加这项研究，因为 以及招募到同一家研究诊所的男性。这个 已经从参与调查的女性那里收集了大量数据 在这项另一项队列研究中，拟议的研究将可用。 特别是在感染HIV-1、HIV-2或 HIV-1和HIV-2，以及在HIV血清阴性的受试者中， 研究人员建议：(1)描述口腔疾病的患病率和性质 与每种艾滋病毒类型相关的损害；以及(2)比较 口腔中可检测到的HIV DNA/RNA与 HIV感染类型及其检测的危险因素。