EPIDEMIOLOGY OF HIV 1 AND HIV 2 ASSOCIATED ORAL DISEASE

描述：本申请提出了一项流行病学研究 西方塞内加尔异性恋女性和男性口腔病变的调查 非洲，可能感染 HIV-1、HIV-2 或同时感染 HIV-1 和 HIV-2 HIV-2 或 HIV 血清阴性者。 据报道，口腔病变 在大量艾滋病毒感染者中发展，并且 因为发展中国家的艾滋病毒感染率更高， 很大一部分患有艾滋病毒相关口腔疾病的患者 病变将来自这些环境。 但很少有系统的 HIV相关口腔疾病的流行病学研究 人口已进行。 许多人报告了口腔病变 HIV-1 感染男性中，但可从以下来源获得的数据要少得多 妇女。 尽管艾滋病与 HIV-2 以及 HIV-1，在许多西非国家，没有公开的数据 关于与 HIV-2 相关的口腔病理风险。 HIV-1、HIV-2 感染者口腔病变的比较研究 或两种 HIV 类型，同时考虑其他潜在风险因素 对于这些病变，由于速度较慢而特别令人感兴趣 与 HIV-1 相比，HIV-2 的免疫功能下降率。 对于 HIV-1 或 HIV-2 的出现频率知之甚少。 在口腔内检测到。 定义口腔疾病的风险和预测因素 HIV-1 和 HIV-2 DNA/RNA 可能对于以下方面很重要 对我们加深对自然的理解的影响 HIV 感染史和 HIV 传播的可能性。 口腔艾滋病毒的存在和数量与体内艾滋病毒的相关性 外周血、CD4 计数和人口特征可能 提供对潜在观察到的差异的见解。 这个 应用程序建议使用基础设施来解决这些问题 它是在塞内加尔开发的传导横截面 (R01CA50856) 和现在的队列 (R01CA46823) HIV 和肿瘤研究。 研究人员计划招募女性参加该研究，因为 以及招募在同一研究诊所就诊的男性。 的 已经从参与的妇女那里收集了大量数据 在这项其他队列研究中，将可用于拟议的研究。 特别是在感染 HIV-1、HIV-2 或 HIV-1 的女性和男性群体中 HIV-1 和 HIV-2 以及 HIV 血清阴性受试者中， 研究者建议：（1）描述口腔疾病的患病率和性质 与每种 HIV 类型相关的病变； (2) 比较数量 口腔中可检测到的 HIV DNA/RNA 感染艾滋病毒的类型及其检测的危险因素。

DESCRIPTION: This application proposes a study of the epidemiology of oral lesions among heterosexual women and men in Senegal, West Africa, who may be infected with either HIV-1, HIV-2, both HIV-1 and HIV-2, or who are HIV seronegative. Oral lesions are reported to develop among a substantial number of HIV infected individuals, and because incidence of HIV infection is greater in developing countries, a large percentage of those patients with HIV associated oral lesions will come from these settings. However, few systematic studies of the epidemiology of HIV associated oral disease in these populations have been undertaken. Many have reported on oral lesions among HIV-1 infected men, but many fewer data are available from women. Although AIDS is associated with HIV-2, as well as with HIV-1, in many West African countries, no published data is available concerning the risk of oral pathology associated with HIV-2. Comparative studies of oral lesions among those with HIV-1, HIV-2, or both HIV types, taking into account other potential risk factors for these lesions, are of particular interest because of the slower rate of immune function decline seen with HIV-2 as compared with HIV-1. Little is known about the frequency with which HIV-1 or HIV-2 can be detected within the oral cavity. Defining risk and predictors of oral HIV-1 and HIV-2 DNA/RNA may be important with respect to implications for our increased understanding of the natural history of HIV infection and potentially of HIV transmission. Correlation of the presence and quantity of oral HIV with HIV in the peripheral blood, CD4 count, and demographic characteristics, may provide insights into potential observed differences. This application proposes to address these issues using the infrastructure which has been developed in Senegal conducting cross-sectional (R01CA50856) and now cohort (R01CA46823) studies of HIV and neoplasia. The investigators plan to recruit women enrolling in that study, as well as to recruit men presenting to the same study clinic. The extensive data already being collected from the women participating in this other cohort study will be available to the proposed study. Specifically among cohorts of women and men with HIV-1, HIV-2, or both HIV-1 and HIV-2, and among HIV seronegative subjects, the investigators propose to: (1) describe the prevalence and nature of oral lesions associated with each HIV type; and (2) compare the quantity of detectable HIV DNA/RNA in the oral cavity with respect to the infecting HIV type and risk factors for its detection.