EARLY ONSET PERIODONTITIS

早发性牙周炎

• 批准号: 6145885
• 负责人: CATHY W CRITCHLOW
• 金额: $ 8.85万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6145885
• 关键词: Africa; adolescence (12-20); blood chemistry; clinical research; dental radiography; disease /disorder onset; disease /disorder proneness /risk; epidemiology; human subject; interview; middle childhood (6-11); oral bacteria; oral health; periodontitis; preschool child (1-5); vertical transmission

Early onset periodontitis (EOP) encompasses a number of periodontal diseases in children and adolescents that result in rapid destruction of the periodontal attachment apparatus leading to pronounced tooth loss. The prevalence of EOP was estimated to be 0% among African-American, 5% among Hispanic, and 1.3? among white adolescents in a national survey among U.S. school children between the ages of 13-17, and 2.1% among the same age group studied as part of NHANES III. Although risk factors for EOP were investigated, relationships between EOP and the microbiological and clinical characteristics of the moth, and effects of the primary dentition and systemic health of children are unknown. Moreover, the occurrence of EOP in systematically compromised children, such as those with human immunodeficiency virus (HIV infection), remain unexplored. We propose a 3 year cross-sectional study to assess the correlates of, and specific risk factors for EOP, and to investigate the clinical features, microbial patterns of transmission, and risk to oral and systemic health associated with EOP in Senegal,, a site where we currently have ongoing studies among women who have on average 5 children between the ages of 4 and 17, in order to evaluate the following specific aims: (1) Determine specific risk factors for EOP in a Senegalese pediatric population by evaluating demographic factors, health history of both the child and mother, and findings from comprehensive oral examinations including measurements of gingival inflammation and decayed, missing and filled teeth; and (2) Compare the prevalence of specific periodontal bacterial pathogens, and the immune responsiveness to those pathogens among children with and without EOP. Furthermore, we propose to assess whether children of moths with specific periodontal bacteria have comparable microbial patterns, and compare children with and without EOP with respect to humoral immune response to specific periodontal pathogens. We will examine 1,100 Senegalese children of mothers currently being followed in ongoing studies. Presence of EOP will be assessed by probe measurements of all teeth, exclusive of the third molars. Mothers will undergo a standardized interview, and children will undergo oral examination and have paperpoint and blood samples collected. Bitewing radiographs (among children greater than 3 years of age with EOP) will be taken to assess the degree of bone loss. The proposed study will contribute important information which may be useful in designing strategies to prevent periodontitis.

早发性牙周炎(EOP)是指儿童和青少年的一系列牙周疾病，这些疾病会导致牙周附着器的迅速破坏，导致牙齿明显脱落。非裔美国人的EOP患病率为0%，西班牙裔为5%，西班牙裔为1.3%。在美国13-17岁学龄儿童中进行的一项全国性调查中，有2.1%的人患有EOP，作为NHANES III的一部分进行研究。尽管对EOP的风险因素进行了调查，但EOP与蛾的微生物学和临床特征的关系以及乳牙列和儿童全身健康的影响尚不清楚。此外，EOP在系统性受损儿童中的发生情况，例如那些感染了人类免疫缺陷病毒(HIV)的儿童，仍未得到探索。我们提议进行一项为期3年的横断面研究，以评估EOP的相关性和特定的风险因素，并调查与EOP相关的临床特征、微生物传播模式以及与塞内加尔EOP相关的口腔和全身健康风险。目前，我们在塞内加尔对平均有5个4至17岁孩子的妇女进行了持续研究，以评估以下具体目标：(1)通过评估人口统计因素、儿童和母亲的健康史以及综合口腔检查的结果，确定塞内加尔儿童人口中EOP的特定风险因素，包括牙龈炎症和龋齿、缺失和充填牙齿的测量；(2)比较患有和不患有牙周炎的儿童中特定牙周细菌的患病率，以及对这些病原体的免疫反应性。此外，我们建议评估患有特定牙周细菌的蛾的儿童是否具有类似的微生物模式，并比较患有和不患有EOP的儿童对特定牙周病原体的体液免疫反应。我们将检查目前正在进行的研究中跟踪调查的1100名母亲的塞内加尔儿童。EOP的存在将通过对所有牙齿(不包括第三磨牙)的探头测量来评估。母亲们将接受标准化的面谈，孩子们将接受口腔检查，并采集纸质纸和血样。将拍摄咬合X光片(在患有EOP的3岁以上儿童中)以评估骨丢失的程度。这项拟议的研究将提供重要的信息，可能有助于设计预防牙周炎的策略。