EPIDEMIOLOGY OF HIV 1 AND HIV 2 ASSOCIATED ORAL DISEASE

HIV 1 和 HIV 2 相关口腔疾病的流行病学

• 批准号: 2132654
• 负责人: CATHY W CRITCHLOW
• 金额: $ 29.49万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2132654
• 关键词: Africa; disease /disorder proneness /risk; epidemiology; human immunodeficiency virus 1; human immunodeficiency virus 2; human subject; oral pharyngeal disorder

DESCRIPTION: This application proposes a study of the epidemiology of oral lesions among heterosexual women and men in Senegal, West Africa, who may be infected with either HIV-1, HIV-2, both HIV-1 and HIV-2, or who are HIV seronegative. Oral lesions are reported to develop among a substantial number of HIV infected individuals, and because incidence of HIV infection is greater in developing countries, a large percentage of those patients with HIV associated oral lesions will come from these settings. However, few systematic studies of the epidemiology of HIV associated oral disease in these populations have been undertaken. Many have reported on oral lesions among HIV-1 infected men, but many fewer data are available from women. Although AIDS is associated with HIV-2, as well as with HIV-1, in many West African countries, no published data is available concerning the risk of oral pathology associated with HIV-2. Comparative studies of oral lesions among those with HIV-1, HIV-2, or both HIV types, taking into account other potential risk factors for these lesions, are of particular interest because of the slower rate of immune function decline seen with HIV-2 as compared with HIV-1. Little is known about the frequency with which HIV-1 or HIV-2 can be detected within the oral cavity. Defining risk and predictors of oral HIV-1 and HIV-2 DNA/RNA may be important with respect to implications for our increased understanding of the natural history of HIV infection and potentially of HIV transmission. Correlation of the presence and quantity of oral HIV with HIV in the peripheral blood, CD4 count, and demographic characteristics, may provide insights into potential observed differences. This application proposes to address these issues using the infrastructure which has been developed in Senegal conducting cross-sectional (R01CA50856) and now cohort (R01CA46823) studies of HIV and neoplasia. The investigators plan to recruit women enrolling in that study, as well as to recruit men presenting to the same study clinic. The extensive data already being collected from the women participating in this other cohort study will be available to the proposed study. Specifically among cohorts of women and men with HIV-1, HIV-2, or both HIV-1 and HIV-2, and among HIV seronegative subjects, the investigators propose to: (1) describe the prevalence and nature of oral lesions associated with each HIV type; and (2) compare the quantity of detectable HIV DNA/RNA in the oral cavity with respect to the infecting HIV type and risk factors for its detection.

产品说明： 本申请提出了一项流行病学研究， 在塞内加尔、西 非洲，可能感染HIV-1、HIV-2、HIV-1和 HIV-2或HIV血清阴性者。 据报道，口腔病变 在大量艾滋病毒感染者中发展， 因为发展中国家的艾滋病毒感染率更高， 很大比例的艾滋病毒相关的口腔 病变将来自这些设置。 然而，很少有系统 研究艾滋病毒相关的口腔疾病的流行病学在这些 人口已经开展。 许多人报告了口腔病变 在HIV-1感染的男性中， 妇女 虽然艾滋病与HIV-2有关， 在许多西非国家，没有公布的数据 关于与HIV-2相关的口腔病理学风险。 HIV-1、HIV-2感染者口腔病变的比较研究， 考虑到其他潜在的风险因素， 对于这些病变，特别感兴趣的是， 与HIV-1相比，HIV-2的免疫功能下降率。 关于HIV-1或HIV-2感染的频率知之甚少。 在口腔内检测到。 定义口腔溃疡的风险和预测因素 HIV-1和HIV-2 DNA/RNA可能对于 对我们日益增长的 理解自然 HIV感染史和潜在HIV传播史。 艾滋病病毒感染者中口服艾滋病病毒的存在和数量与艾滋病病毒的相关性 外周血，CD4计数和人口统计学特征，可能 提供对潜在观察到的差异的见解。 这 应用程序建议使用基础架构解决这些问题 这是在塞内加尔发展起来的， （R01CA50856）和现在的队列（R01CA46823）研究。 研究人员计划招募参与该研究的女性， 以及招募到同一研究诊所就诊的男性。 的 已经从参与的妇女那里收集了大量数据， 在这另一个队列研究将提供给拟议的研究。 特别是在艾滋病毒1型、艾滋病毒2型或 HIV-1和HIV-2，在HIV血清阴性受试者中， 研究人员建议：（1）描述口腔疾病的患病率和性质 与每种HIV类型相关的病变;以及（2）比较 口腔中可检测到的HIV DNA/RNA， 感染艾滋病毒的类型和危险因素的检测。