DETECTION OF PRESYMPTOMATIC ALZHEIMER DISEASE BY FMRI

通过 FMRI 检测症状前阿尔茨海默病

• 批准号: 2383953
• 负责人: Charles Dennis Smith
• 金额: $ 18.2万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2383953
• 关键词: Alzheimer's disease; aging; alleles; apolipoproteins; biomarker; brain disorder diagnosis; cerebral dominance; clinical research; cognition disorders; differential semantics; disease /disorder proneness /risk; family genetics; functional magnetic resonance imaging; genotype; human middle age (35-64); human subject; magnetic resonance imaging; mathematical model; neuroanatomy; neurobiology; neuropathology; neuropsychological tests; statistics /biometry

This application proposes to study functional MRI, structural MRI, and neuropsychological function in individuals at different levels of risk for Alzheimer's Disease. The risk groups will be defined by family history and by apolipoprotein-E allele status. The major hypothesis is that the pattern and extent of cortical activation during a visual confrontation naming task will differ substantially between subjects at high and low risk for AD. The investigators will also determine whether structural/anatomic differences exist between the groups and whether these MRI findings correlate with neuropsychological function. This application addresses a very important area in AD research. The preliminary fMRI data would be stronger if it included elderly subjects or these at risk for AD. The use of two different strategies for identifying intermediate risk groups may pose some difficulties and interpretation. The primary analyses of fMRI data is group mean data rather date released: 04/04/1997.

本申请旨在研究功能 MRI、结构 MRI、 以及不同水平个体的神经心理功能 阿尔茨海默病的风险。 风险组将定义为 家族史和载脂蛋白-E 等位基因状态。 主要 假设是大脑皮层激活的模式和程度 视觉对抗命名任务之间会有很大差异 AD高风险和低风险的受试者。调查人员还将 确定之间是否存在结构/解剖学差异 组以及这些 MRI 结果是否与相关 神经心理功能。 该应用程序解决了一个非常 AD 研究的重要领域。 初步的功能磁共振成像数据是 如果其中包括老年受试者或有 AD 风险的受试者，则效果会更强。 这 使用两种不同的策略来识别中等风险群体 可能会造成一些困难和解释。 初步分析 fMRI 数据是组平均数据，而不是发布日期：04/04/1997。