Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research Scanner

这是一个多用户设备授权申请，用于将Siemens Prisma Fit升级到 肯塔基州大学MRISC中现有的Magnetom 3 T TIM Trio MR扫描仪。 之所以要求提供资金支持这一升级，是因为 Prisma系统用于生物医学研究，特别是用于一组富有成效的NIH资助的 参与神经科学研究的研究人员。Prisma系统将成为 保持和扩大这组研究人员的研究计划。 在新仪器的许多优点中，最重要的包括： 改进的磁场梯度系统（更高的振幅和改进的占空比）， 使白色物质结构的详细研究成为可能，这是目前Trio无法实现的 系统升级将包括一个改进的射频（RF）系统，其中包括一个 使RF接收通道的数量加倍。由此产生的更高的信噪比和更高的 高分辨率图像将使人们对大脑退化和重塑有新的认识。的 Prisma上的并行发射系统将改善激发的均匀性，并实现2D 用于减小FOV成像的选择性激励。最先进的计算机系统， 升级中还包括一个编程环境，将有助于加强协作 与其他生物医学研究人员合作，并走上正规系统现代化的道路。PI和 多个共同首席信息官（co-PI）组成了该应用程序的主要用户组，他们资助了一些项目 从神经科学的基础研究到临床神经科学研究项目。 他们的研究将大大受益于这种先进的仪器， 在大学或其他地方。通过大学的磁共振 成像和光谱中心，也管理一个小动物，高场磁共振成像仪， 基础设施（包括空间、财务管理、日常维护、技术 支持和人员）的存在，以迅速使新的扫描仪上线时，资金变得 它将继续发展其援助生物医学研究的能力。

This is a multiuser equipment grant application for a Siemens Prisma Fit upgrade to the existing Magnetom 3T TIM Trio MR scanner in the MRISC at the University of Kentucky. Funding to support this upgrade is being requested because of the significant advantages of the Prisma system for biomedical research particularly for a group of productive, NIH-funded investigators involved in neuroscience research. The Prisma system will be integral to maintaining and expanding the research program of this group of investigators. Among the many advantages of the new instrument the most significant include the improved magnetic field gradient system, (higher amplitude and improved duty cycle) which will enable studies of white matter structure in a detail which is unavailable on the current Trio system. The upgrade will include an improved radiofrequency (RF) system which includes a doubling of the number of RF receive channels. The resulting higher signal-to-noise and higher resolution images will enable newer insights into brain degeneration and remodeling. The parallel transmit system on the Prisma will improve the homogeneity of excitation and enable 2D selective excitation for reduced FOV imaging. A state-of-the-art computer system and programming environment also included in the upgrade will facilitate enhanced collaboration with other biomedical researchers and a path to regular system modernization. The PI and multiple co-PIs, which form the Major Users Group on this application, have funded programs ranging from fundamental studies in neuroscience to clinical neuroscience research programs. Their research will significantly benefit from this advanced instrumentation which is not available at the University or elsewhere in the State. Through the University’s Magnetic Resonance Imaging and Spectroscopy Center which also manages a small animal, high field MR imager, the infrastructure (including space, financial management, routine maintenance, technical support and personnel) exists to rapidly bring the new scanner on line when funding becomes available and to continue to develop its capabilities to aid biomedical research.