Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research Scanner

这是西门子Prisma Fit升级到的多用户设备授权申请 现有的Magnetom 3T Tim Trio MR扫描仪位于肯塔基大学的MRISC。 正在申请资金以支持此次升级，因为 PRISMA系统用于生物医学研究，特别适用于由NIH资助的生产性群体 参与神经科学研究的研究人员。PRISMA系统将成为 维持和扩大这批调查人员的研究计划。 在新工具的许多优点中，最重要的包括 改进的磁场梯度系统(更高的幅度和更好的占空比)，将 能够对白质结构进行详细的研究，这在当前的Trio中是不可用的 系统。此次升级将包括改进的射频(RF)系统，其中包括 将射频接收通道的数量翻倍。由此产生更高的信噪比和更高的 分辨率图像将使人们能够对大脑退化和重塑有更新的了解。这个 棱镜上的并行传输系统将改善激励的均匀性并实现2D 用于减少视野成像的选择性激发。一种最先进的计算机系统和 升级中还包括编程环境，这将有助于增强协作 与其他生物医学研究人员合作，并走上常规系统现代化的道路。圆周率和 组成该应用程序的主要用户组的多个合作PI已为项目提供资金 范围从神经科学的基础研究到临床神经科学研究项目。 他们的研究将大大受益于这种先进的仪器，而这种仪器是不可用的 在大学或本州的其他地方。通过大学的磁共振 成像和光谱中心还管理着一个小动物，高场磁共振成像仪， 基础设施(包括空间、财务管理、日常维护、技术 支持和人员)，以便在资金到位后迅速使新扫描仪上线 可利用的，并继续发展其能力，以协助生物医学研究。

This is a multiuser equipment grant application for a Siemens Prisma Fit upgrade to the existing Magnetom 3T TIM Trio MR scanner in the MRISC at the University of Kentucky. Funding to support this upgrade is being requested because of the significant advantages of the Prisma system for biomedical research particularly for a group of productive, NIH-funded investigators involved in neuroscience research. The Prisma system will be integral to maintaining and expanding the research program of this group of investigators. Among the many advantages of the new instrument the most significant include the improved magnetic field gradient system, (higher amplitude and improved duty cycle) which will enable studies of white matter structure in a detail which is unavailable on the current Trio system. The upgrade will include an improved radiofrequency (RF) system which includes a doubling of the number of RF receive channels. The resulting higher signal-to-noise and higher resolution images will enable newer insights into brain degeneration and remodeling. The parallel transmit system on the Prisma will improve the homogeneity of excitation and enable 2D selective excitation for reduced FOV imaging. A state-of-the-art computer system and programming environment also included in the upgrade will facilitate enhanced collaboration with other biomedical researchers and a path to regular system modernization. The PI and multiple co-PIs, which form the Major Users Group on this application, have funded programs ranging from fundamental studies in neuroscience to clinical neuroscience research programs. Their research will significantly benefit from this advanced instrumentation which is not available at the University or elsewhere in the State. Through the University’s Magnetic Resonance Imaging and Spectroscopy Center which also manages a small animal, high field MR imager, the infrastructure (including space, financial management, routine maintenance, technical support and personnel) exists to rapidly bring the new scanner on line when funding becomes available and to continue to develop its capabilities to aid biomedical research.