Essential Siemens Prisma Fit Upgrade for the University of Kentucky 3T Research Scanner

这是一份多用户设备拨款申请，用于将西门子 Prisma Fit 升级到 肯塔基大学 MRISC 中现有的 Magnetom 3T TIM Trio MR 扫描仪。 由于该技术的显着优势，正在请求资金支持此次升级。 用于生物医学研究的 Prisma 系统，特别是针对一组由 NIH 资助的富有成效的研究人员 参与神经科学研究的研究者。 Prisma 系统将成为 维持和扩大这组研究人员的研究计划。 在新仪器的众多优点中，最显着的包括 改进的磁场梯度系统（更高的振幅和改进的占空比），这将 能够对白质结构进行详细研究，这是当前 Trio 无法实现的 系统。此次升级将包括改进的射频 (RF) 系统，其中包括 RF 接收通道数量加倍。由此产生的更高的信噪比和更高的 高分辨率图像将使人们能够对大脑退化和重塑有新的认识。的 Prisma 上的并行传输系统将提高激励的均匀性并实现 2D 用于缩小视场成像的选择性激发。最先进的计算机系统和 升级中还包括编程环境，将有助于加强协作 与其他生物医学研究人员合作以及通向常规系统现代化的道路。 PI 和 构成此应用程序主要用户组的多个共同 PI 已资助项目 范围从神经科学的基础研究到临床神经科学研究项目。 他们的研究将大大受益于这种目前无法获得的先进仪器 在大学或州内其他地方。通过大学的磁共振 成像和光谱中心还管理小动物、高场 MR 成像仪、 基础设施（包括空间、财务管理、日常维护、技术 支持和人员）的存在，以便在资金到位时快速使新扫描仪上线 并继续发展其能力以协助生物医学研究。

This is a multiuser equipment grant application for a Siemens Prisma Fit upgrade to the existing Magnetom 3T TIM Trio MR scanner in the MRISC at the University of Kentucky. Funding to support this upgrade is being requested because of the significant advantages of the Prisma system for biomedical research particularly for a group of productive, NIH-funded investigators involved in neuroscience research. The Prisma system will be integral to maintaining and expanding the research program of this group of investigators. Among the many advantages of the new instrument the most significant include the improved magnetic field gradient system, (higher amplitude and improved duty cycle) which will enable studies of white matter structure in a detail which is unavailable on the current Trio system. The upgrade will include an improved radiofrequency (RF) system which includes a doubling of the number of RF receive channels. The resulting higher signal-to-noise and higher resolution images will enable newer insights into brain degeneration and remodeling. The parallel transmit system on the Prisma will improve the homogeneity of excitation and enable 2D selective excitation for reduced FOV imaging. A state-of-the-art computer system and programming environment also included in the upgrade will facilitate enhanced collaboration with other biomedical researchers and a path to regular system modernization. The PI and multiple co-PIs, which form the Major Users Group on this application, have funded programs ranging from fundamental studies in neuroscience to clinical neuroscience research programs. Their research will significantly benefit from this advanced instrumentation which is not available at the University or elsewhere in the State. Through the University’s Magnetic Resonance Imaging and Spectroscopy Center which also manages a small animal, high field MR imager, the infrastructure (including space, financial management, routine maintenance, technical support and personnel) exists to rapidly bring the new scanner on line when funding becomes available and to continue to develop its capabilities to aid biomedical research.