Upgrade to Multiuser 3T Magnetic Resonance Imager

升级到多用户 3T 磁共振成像仪

• 批准号: 7596804
• 负责人: Charles Dennis Smith
• 金额: $ 50万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-04 至 2010-05-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7596804
• 关键词: Affect; Aging; Alcoholism; Alzheimer' s Disease; Anatomy; Area; Arts; Autistic Disorder; Behavior; Biological Markers; Brain; Data; Degenerative Disorder; Dementia; Development; Diagnosis; Diffusion; Disease; Early Diagnosis; Equipment; Funding; Future; Goals; Grant; Human; Huntington Disease; Image; Imaging Techniques; Individual; Investigation; Kentucky; Magnetic Resonance; Measurement; Measures; Methodology; Nerve Degeneration; Neurodegenerative Disorders; Neurologic; Neurosciences; Neurosciences Research; Noise; Parkinson Disease; Positioning Attribute; Public Health; Research; Research Personnel; Research Project Grants; Screening procedure; Signal Transduction; Speed; Spinal Cord; Structure; System; Techniques; Technology; Therapeutic; United States National Institutes of Health; Universities; Weight; data acquisition; improved; instrument; instrumentation; nervous system disorder; normal aging; novel; programs; public health relevance; radiofrequency; reconstruction; spectroscopic imaging; tool; white matter

DESCRIPTION (provided by applicant): This proposal is for funding to upgrade a high-end 3T Siemens Trio MR imager at the University of Kentucky. The upgrade includes improvements to the gradients, the radiofrequency transmitter and receiver systems, and data acquisition and reconstruction systems of the imager and will significantly improve the imaging capabilities of the instrument, bringing it up to the state-of-the-art and providing a platform for future upgrades. The upgrade is essential to providing continued support for an outstanding group of eleven NIH funded researchers using this instrument as the central piece of experimental apparatus for their neuroscience research into developmental and degenerative diseases such as Parkinson's and Alzheimer's. The rapid development of MR technology and neuroscience research necessitates this upgrade and will position UK researchers to advance research into aging, dementia and other neurological diseases. With this upgrade UK neuroscience researchers will have the most sensitive imaging techniques to investigate non-invasively the causes and consequences of neurological diseases. In particular, the specific aims of this upgrade are to improve both the speed and signal-to- noise of image acquisition, the accuracy of image and spectroscopic measurements and to enable the acquisition of novel diffusion weighted data necessary to explore white matter structure and function. The equipment upgrade will benefit many important cutting-edge research projects such as the development of sensitive tools for early detection of Alzheimer's and Parkinson's diseases, understanding the areas of the brain involved in alcoholism and autism and understanding the connection between brain structure and behavior and function. The upgrade supports the long term goal of this group, which is the development of methodologies and tools for the study of brain anatomy and function in normal individuals and in subjects affected with neurodegenerative or congenital neurological conditions. The relevance of this equipment upgrade is that it will provide a nationally recognized group of neuroscience investigators with state-of-the-art research tools to greatly expand and enhance their investigations into the changes in the brain and spinal cord which occur with diseases such as Alzheimer's and Parkinson's as well as with normal aging and with therapeutic treatments including biomarkers for these conditions. Expanding this research program is crucial as the techniques developed from non-invasive imaging can easily and rapidly be applied to advancing public health through improved screening and diagnosis. PUBLIC HEALTH RELEVANCE: This Shared Instrumentation Grant will upgrade a multi-user, high field, MR imager to a state-of-the-art instrument for carrying out advanced neuroscience research at the University of Kentucky. The upgrade will add several new acquisition and analysis features to measure, through non-invasive imaging, the structure and function of the brain. These improvements are essential to continue research into the origin and causes of several neurodegenerative diseases including Parkinson's, Alzheimer's, Huntington's as well as normal human aging.

描述（由申请人提供）：该提案是为了资助肯塔基大学的高端3T Siemens Trio MR Imager。升级包括对梯度的改进，射频发射器和接收器系统以及成像仪的数据采集和重建系统的改进，并将显着提高仪器的成像功能，从而将其提升到最先进的艺术品，并为未来的升级提供平台。升级对于为持续支持的11名NIH资助的研究人员提供了持续的支持，该研究人员使用该工具作为其神经科学研究的中心实验设备，以研究帕克森和阿尔茨海默氏症等发育和退化性疾病。 MR技术和神经科学研究的快速发展需要进行此升级，并将英国研究人员定位，以推动对衰老，痴呆症和其他神经系统疾病的研究。通过这种升级，英国神经科学研究人员将拥有最敏感的成像技术，以非侵入性地研究神经系统疾病的原因和后果。特别是，此升级的具体目的是提高图像采集的速度和信号噪声，图像和光谱测量的准确性，并能够获得探索白质结构和功能所需的新型扩散加权数据。该设备升级将使许多重要的尖端研究项目受益，例如开发敏感工具，以早日检测阿尔茨海默氏病和帕金森氏病，了解涉及酒精中毒和自闭症的大脑领域，并了解大脑结构和行为与行为和功能之间的联系。升级支持该组的长期目标，这是用于研究正常个体的方法和工具的开发，以及受神经退行性或先天性神经系统疾病的受试者的功能。该设备升级的相关性是，它将为一组全国认可的神经科学研究人员提供最先进的研究工具，以极大地扩展和增强他们对大脑和脊髓变化的研究，这些变化发生在阿尔茨海默氏症和帕金森氏症，以及与正常的治疗以及包括这些条件在内的生物治疗的疾病，包括这些条件。扩大该研究计划至关重要，因为通过非侵入性成像开发的技术可以轻松而迅速地应用于通过改进的筛查和诊断来推进公共卫生。 公共卫生相关性：这种共同的仪器赠款将升级多用户，高领域的先生Imager先生，以在肯塔基大学进行高级神经科学研究的最先进工具。升级将添加一些新的获取和分析功能，以通过非侵入性成像，大脑的结构和功能来衡量。这些改进对于继续研究几种神经退行性疾病的起源和原因至关重要，包括帕金森氏症，阿尔茨海默氏症，亨廷顿以及正常的人类衰老。