A High-Field Small Animal MR Imager for Biomedical Research

用于生物医学研究的高场小动物 MR 成像仪

• 批准号: 7839523
• 负责人: Charles Dennis Smith
• 金额: $ 309.59万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-27 至 2012-05-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7839523
• 关键词: Animals; Area; Arts; Biomedical Research; Cardiovascular system; Clinical; Complex; Computer software; Core Facility; Development; Electronics; Funding; Grant; Housing; Human; Human Subject Research; Image; Injury; Kentucky; Magnetic Resonance Imaging; Malignant Neoplasms; Medical; Mus; Protocols documentation; Rattus; Research; Research Personnel; Rodent; Site; Solutions; Spectrum Analysis; System; Translations; United States National Institutes of Health; Universities; animal colony; experience; in vivo; innovation; instrument; instrumentation; nonhuman primate; pre-clinical; radiofrequency; research study

DESCRIPTION (provided by applicant): This grant is to support the acquisition of a high-field small animal imager to support multiple NIH- funded investigators using small animals for biomedical research. The imager selected is a 7T Bruker ClinScan system which incorporates the advantages of Bruker magnet, gradient coil and radiofrequency coil with the expertise and accomplishments of Siemens Medical Solutions to produce the RF electronics and controlling software. That the new imager will operate using syngo software which is the same as used on the Siemens TIM Trio also housed in the Magnetic Resonance Imaging and Spectroscopy Center (MRISC) will facilitate translation of imaging protocols between experimental animals and human research subjects and will aid in the acquisition of optimal imaging protocols on complex studies. The instrument will be installed in and administered by MRISC - a university core facility dedicated to the development of innovative preclinical and experimental MR imaging of experimental animals and humans. The imager will be operated and maintained by a group of experienced MR researchers. The imager will be sited next to the animal colony facility which houses non-human primates, as well as rats and mice used for a variety of research studies. PUBLIC HEALH RELEVANCE: This High End Instrumentation Grant will provide a high field, MR imager suitable for small animal in vivo imager to a multi-user group of productive, NIH-funded, biomedical researchers. This instrument will replace the current use of a clinical imager, ill suited for imaging rodents, with a state-of-the-art, high field imager suitable for research into traumatic injury, cancer, cardiovascular and several other areas of research currently underway at the University of Kentucky.

描述（由申请人提供）：该补助金用于支持购买高视场小动物成像仪，以支持多个NIH资助的研究人员使用小动物进行生物医学研究。所选的成像仪是7 T Bruker ClinScan系统，该系统结合了Bruker磁体、梯度线圈和射频线圈的优势以及Siemens Medical Solutions的专业知识和成就，以生产射频电子器件和控制软件。新成像仪将使用syngo软件运行，该软件与磁共振成像和光谱学中心（MRISC）的Siemens TIM Trio上使用的软件相同，这将有助于实验动物和人类研究对象之间的成像协议翻译，并有助于在复杂研究中获得最佳成像协议。该仪器将安装在MRISC中并由其管理-MRISC是一所大学的核心设施，致力于开发实验动物和人类的创新临床前和实验MR成像。成像仪将由一组经验丰富的MR研究人员操作和维护。该成像仪将放置在动物群落设施旁边，该设施饲养非人类灵长类动物以及用于各种研究的大鼠和小鼠。 公共卫生相关性：这项高端仪器补助金将为NIH资助的多用户生物医学研究人员提供适用于小动物体内成像仪的高场MR成像仪。该仪器将取代目前使用的临床成像仪，不适合成像啮齿动物，与一个国家的最先进的，高场成像适合研究到创伤性损伤，癌症，心血管和其他几个领域的研究目前正在进行中的肯塔基州大学。

项目成果

Regional quantification of myocardial mechanics in rat using 3D cine DENSE cardiovascular magnetic resonance.

• DOI: 10.1002/nbm.3733
• 发表时间: 2017-08
• 期刊: NMR IN BIOMEDICINE
• 影响因子: 2.9
• 作者: Zhang, Xiaoyan;Liu, Zhan-Qiu;Singh, Dara;Wehner, Gregory J.;Powell, David K.;Campbell, Kenneth S.;Fornwalt, Brandon K.;Wenk, Jonathan F.
• 通讯作者: Wenk, Jonathan F.

Extended Middle Cerebral Artery Occlusion (MCAO) Model to Mirror Stroke Patients Undergoing Thrombectomy.

• DOI: 10.1007/s12975-021-00936-y
• 发表时间: 2022-08
• 期刊: Translational stroke research
• 影响因子: 6.9
• 作者: Messmer SJ;Salmeron KE;Frank JA;McLouth CJ;Lukins DE;Hammond TC;Lin AL;Fraser JF;Pennypacker KR
• 通讯作者: Pennypacker KR

Reduced Efficacy of Anti-Aβ Immunotherapy in a Mouse Model of Amyloid Deposition and Vascular Cognitive Impairment Comorbidity.

淀粉样蛋白沉积和血管认知障碍合并症小鼠模型中抗 Aβ 免疫疗法的功效降低。

• DOI: 10.1523/jneurosci.1762-16.2016
• 发表时间: 2016
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Weekman,EricaM;Sudduth,TiffanyL;Caverly,CarlyN;Kopper,TimothyJ;Phillips,OliverW;Powell,DaveK;Wilcock,DonnaM
• 通讯作者: Wilcock,DonnaM

Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.

• DOI: 10.1161/atvbaha.114.304683
• 发表时间: 2015-01
• 期刊: Arteriosclerosis, thrombosis, and vascular biology
• 作者: Davis FM;Rateri DL;Balakrishnan A;Howatt DA;Strickland DK;Muratoglu SC;Haggerty CM;Fornwalt BK;Cassis LA;Daugherty A
• 通讯作者: Daugherty A

Gut microbial dysbiosis correlates with stroke severity markers in aged rats.

• DOI: 10.3389/fstro.2022.1026066
• 发表时间: 2022-01-01
• 期刊: Frontiers in stroke
• 作者: Hammond, Tyler C;Messmer, Sarah;Pennypacker, Keith R
• 通讯作者: Pennypacker, Keith R