NEURONAL PATHWAYS OF THE BASAL GANGLIA

描述：本研究的最终目标是促进 了解基底神经节在运动控制中的功能。 的 对基底神经节回路的精确了解对于 基底神经节研究的理论和实际应用 紊乱 本建议的目的是实现以下两个目标 明确的目标。 第一个具体目标是证实我的假设， 皮质信号被传输到基底神经节输出核， 脚内核和黑质网状部，通过两个 不同的核团，新纹状体和丘脑底核。 的 研究人员将研究刺激感觉运动皮层是否 在基底神经节输出核中诱导双突触兴奋， 通过丘脑底核介导，和双突触抑制， 是通过新纹状体介导的 第二个具体目标是测试我的 苍白球是基底节控制中心的假说 苍白球汇聚来自新纹状体的输入 丘脑底核和苍白球的输出控制着 整个基底神经节的活动 研究者的研究，如 以及其他人的研究表明苍白球 整合来自新纹状体和丘脑底核的输入。 的 苍白球也大量投射到新纹状体和基底 神经节输出核、脚内核和黑质 网状部 研究人员的研究将重点关注以下因素的影响 苍白球投射到新纹状体和脚内核。 这项研究将描述生理特性和作用， 苍白球投射到新纹状体和脚内核。 在 建议的项目结束时，他们将能够提供一个解剖 以及解释GP神经元活动的生理基础 影响其他基底神经节核团。 拟议研究的方法 包括：单位记录、细胞内记录和染色 麻醉动物和脑切片制备物。

DESCRIPTION: The ultimate goal of the study is to contribute to the understanding of the function of the basal ganglia in movement control. The precise knowledge of the circuitry of the basal ganglia is important for both theoretical and practical application to the study of basal ganglia disorders. The purpose of this proposal is to achieve the following two specific aims. The first specific aim is to substantiate my hypothesis that cortical signals are transmitted to the basal ganglia output nuclei, the entopeduncular nucleus and the substantia nigra pars reticulata, through two different nuclei, the neostriatum and the subthalamic nucleus. The investigators will examine whether stimulation of the sensorimotor cortex induces, in basal ganglia output nuclei, a disynaptic excitation which is mediated through the subthalamic nucleus, and a disynaptic inhibition which is mediated through the neostriatum. The second specific aim is to test my hypothesis that the globus pallidus is the control center of the basal ganglia in that the globus pallidus converges inputs from the neostriatum and the subthalamic nucleus and the output of the globus pallidus controls the activity of the entire basal ganglia. The investigator's studies, as well as those of others, have demonstrated that the globus pallidus integrates inputs from the neostriatum and the subthalamic nucleus. The globus pallidus also projects heavily to the neostriatum and the basal ganglia output nuclei, the entopeduncular nucleus and the substantia nigra pars reticulata. The investigators study will focus on the effects of pallidal projections to the neostriatum and the entopeduncular nucleus. This study will characterize physiological properties and the role of pallidal projections to the neostriatum and the entopeduncular nucleus. At the end of the proposed projects, they will be able to offer an anatomical and physiological basis for explaining how the activity of GP neurons influence other basal ganglia nuclei. The methods for the proposed study include: unit recording, intracellular recording and staining in both anesthetized animals and brain slice preparations.