Next Generation Flow Diverter for the Treatment of Intracranial Aneurysms

用于治疗颅内动脉瘤的下一代分流器

• 批准号: 71494
• 金额: $ 44.6万
• 依托单位: OXFORD ENDOVASCULAR LIMITED
• 依托单位国家: 英国
• 项目类别: Study
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=71494
• 关键词: Next; Generation; Flow; Diverter; Treatment

Annually 6,600 UK citizens suffer a subarachnoid haemorrhage (SAH) resulting from the rupture of an intracranial aneurysm (IA), of whom 40% will die and 40% will suffer severe disabilities. However, SAH's are entirely avoidable through early intervention.Over the last decades clinical interventions have increasingly moved from invasive, risky, and expensive open surgeries (clipping) to less risky and cheaper minimally invasive endovascular coiling. Here coils are used to fill the aneurysm and prevent growth/rupture. However, for wide necked aneurysms, coils can dislodge and migrate into the parent artery leading to risk of thrombosis and stroke. To address this challenge stents are placed over the aneurysm neck. However, this is expensive, has limited efficacy and introduces new risks (clot formation).Flow diverters (FDs) are an emerging endovascular device (mesh structure) that is placed over the aneurysm to divert blood flow away, thereby prevent growth/rupture and enabling natural healing. By their nature, FD have the potential to effectively treat complex and wide-necked aneurysms.However, existing FDs have failed to live up to expectations, reporting performance inferior to coiling. Limitations are inherent to the FD mesh design that drives weak and non-uniform radial forces, resulting in incomplete opening, poor vessel apposition, variable porosity and device coning, and leading to suboptimal IA occlusion, FD migration and risk of thrombosis/stroke.OE seek to overcome these challenges through development of a novel 'origami inspired' engineered FD.

每年有6，600名英国公民因颅内动脉瘤（IA）破裂而遭受蛛网膜下腔出血（SAH），其中40%将死亡，40%将遭受严重残疾。然而，通过早期干预，SAH是完全可以避免的。在过去的几十年中，临床干预越来越多地从侵入性、风险性和昂贵的开放手术（夹闭）转向风险较小且更便宜的微创血管内弹簧圈栓塞术。在这里，弹簧圈用于填充动脉瘤并防止生长/破裂。然而，对于宽颈动脉瘤，弹簧圈可能移位并迁移到载瘤动脉中，导致血栓形成和卒中风险。为了应对这一挑战，将支架放置在动脉瘤颈上。然而，这是昂贵的，具有有限的功效并且引入了新的风险（凝块形成）JDs）是一种新兴的血管内装置（网状结构），其被放置在动脉瘤上以将血流转移开，从而防止生长/破裂并且实现自然愈合。就其性质而言，FD具有有效治疗复杂和宽颈动脉瘤的潜力。然而，现有的FD未能达到预期，报告性能不如弹簧圈栓塞。FD补片设计固有的局限性是驱动弱且不均匀的径向力，导致不完全打开、血管贴壁不良、可变孔隙率和器械锥形，并导致次优IA闭塞、FD移位和血栓形成/卒中风险。OE试图通过开发新型“折纸灵感”工程FD来克服这些挑战。