TRANSITION METAL ROUTE TO XESTOBERGSTEROL

描述（改编自申请人的摘要）：过渡金属 合成xestobergsterol-A和-B的介导方法是 介绍了 该项目的主要目标是：（1）综合 对映体纯形式的xestobergsterol-A和xestobergsterol-B， (2)开发综合方法来解决不可避免的 （3）提供一种合成途径， 生物学试验用衍生物，（4）提交生物学试验用中间体 生物学分析，以及（5）确定所需的官能团 生物活性。 综合的方法 xestobergsterols涉及使用关键的过渡金属介导的烯， 炔环化以构建分子的双环（3.3.0）部分。 在合成策略中，计划合成左手 部分和路线的立体选择性合成的右手 环系统的一侧进行描述。 两者的最终合并 这些方法将导致xestobergsterols的合成。 的 在xestobergsterols的方法中开发的化学应该是 适用于其他生物分子的全合成， 兴趣

DESCRIPTION (adapted from applicant's abstract): A transition metal mediated approach to the synthesis of xestobergsterol-A and -B is described. The primary goals of the project are to: (1) synthesize xestobergsterol-A and xestobergsterol-B in enantiomericallypure form, (2) develop synthetic methods to solve problems that will inevitably arise, (3) provide a synthetic route that will permit access to derivatives for biological testing, (4) submit the intermediates for biological analysis, and (5) determine the functional groups necessary for biological activity. The approach to the synthesis of the xestobergsterols involves the use of a key transition metal mediated ene- yne cyclization to construct the bicyclo(3.3.0) portion of the molecule. Within the synthetic strategy, plans for the synthesis of the left hand portion and routes to the stereoselective synthesis of the right hand side of the ring system are described. The ultimate merger of the two approaches will lead to the synthesis of the xestobergsterols. The chemistry developed in the approach to the xestobergsterols should be applicable to the total synthesis of other molecules of biological interest