TRANSITION METAL ROUTE TO XESTOBERGSTEROL

描述(摘自申请者的摘要)：一种过渡金属 介导法合成xestobergsterol-A和-B 描述。该项目的主要目标是：(1)合成 Xestobergsterol-A和xestobergsterol-B以对映体形式存在， (2)开发综合方法来解决不可避免的问题 产生，(3)提供一条合成路线，允许进入 用于生物检测的衍生物；(4)提交用于生物检测的中间体 生物分析，以及(5)确定所需的官能团 用于生物活动。二氢呋喃类化合物的合成方法 Xestobergsterol涉及到一种关键的过渡金属介导的烯- 乙炔环化以构建分子的双环(3.3.0)部分。 在合成策略中，左手的合成计划 右手立体选择性合成的部位和途径 对环网系统的侧面进行了描述。两者的最终合并 这些方法将导致xestobergsterol的合成。这个 化学方法发展的xestobergsterol应该是 适用于其他生物分子的全合成 利息

DESCRIPTION (adapted from applicant's abstract): A transition metal mediated approach to the synthesis of xestobergsterol-A and -B is described. The primary goals of the project are to: (1) synthesize xestobergsterol-A and xestobergsterol-B in enantiomericallypure form, (2) develop synthetic methods to solve problems that will inevitably arise, (3) provide a synthetic route that will permit access to derivatives for biological testing, (4) submit the intermediates for biological analysis, and (5) determine the functional groups necessary for biological activity. The approach to the synthesis of the xestobergsterols involves the use of a key transition metal mediated ene- yne cyclization to construct the bicyclo(3.3.0) portion of the molecule. Within the synthetic strategy, plans for the synthesis of the left hand portion and routes to the stereoselective synthesis of the right hand side of the ring system are described. The ultimate merger of the two approaches will lead to the synthesis of the xestobergsterols. The chemistry developed in the approach to the xestobergsterols should be applicable to the total synthesis of other molecules of biological interest