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REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS

REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS
3 个增强子对人类 IGH 基因座的调节
批准号：
2673043
负责人：
Barbara Birshtein
金额：
$15.78万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-15 至 2002-08-31
来源：
https://reporter.nih.gov/project-details/2673043
关键词：
animal genetic material tag gene expression gene rearrangement genetic enhancer element genetic mapping genetic regulation human genetic material tag immunoglobulin genes molecular cloning nucleic acid probes tissue /cell culture transcription factor

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英文摘要
The investigator's group has surmounted some cloning barriers and has succeeded in identifying two virtually identical enhancers, one located approximately 10 kb 3' of each of the two human C alpha genes. These enhancers contain a 191 bp segment of homology to the murine enhancer 3'aE (Hst2). They wish to study the regulation of the human C alpha associated enhancers, to further map these downstream regions and assess them for additional enhancers which they predict to be present, and to acquired variations that influence IgH gene expression in normal, immunodeficient and malignant states.
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