课题基金 / 基金详情

REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS

REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS
3 个增强子对人类 IGH 基因座的调节
批准号：
6373659
负责人：
Barbara Birshtein
金额：
$17.22万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-15 至 2003-08-31
来源：
https://reporter.nih.gov/project-details/6373659
关键词：
animal genetic material tag gene expression gene rearrangement genetic enhancer element genetic mapping genetic regulation human genetic material tag immunoglobulin genes molecular cloning nucleic acid probes tissue /cell culture transcription factor

项目摘要

项目成果

Barbara Birshtein的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
The investigator's group has surmounted some cloning barriers and has succeeded in identifying two virtually identical enhancers, one located approximately 10 kb 3' of each of the two human C alpha genes. These enhancers contain a 191 bp segment of homology to the murine enhancer 3'aE (Hst2). They wish to study the regulation of the human C alpha associated enhancers, to further map these downstream regions and assess them for additional enhancers which they predict to be present, and to acquired variations that influence IgH gene expression in normal, immunodeficient and malignant states.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Comparative analysis of human and mouse 3' Igh regulatory regions identifies distinctive structural features.
对人和小鼠 3 Igh 调节区的比较分析确定了独特的结构特征。
DOI： 10.1016/j.molimm.2004.09.006
发表时间： 2005
期刊： Molecular immunology
影响因子： 3.6
作者： [Sepulveda,ManuelA, Garrett,FrancineE, Price-Whelan,Alexa, Birshtein,BarbaraK]
通讯作者： Birshtein,BarbaraK
Bronx Einstein Training in Teaching and Research (BETTR)
Bronx Einstein Training in Teaching and Research (BETTR)
Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA program
Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA program
海外基金