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REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS

REGULATION OF HUMAN IGH GENE LOCUS BY 3 ENHANCERS
3 个增强子对人类 IGH 基因座的调节
批准号：
2382593
负责人：
Barbara Birshtein
金额：
$15.59万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-09-15 至 2002-09-14
来源：
https://reporter.nih.gov/project-details/2382593
关键词：
animal genetic material tag gene expression gene rearrangement genetic enhancer element genetic mapping genetic regulation human genetic material tag immunoglobulin genes molecular cloning nucleic acid probes tissue /cell culture transcription factor

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中文摘要
翻译
该研究小组已经克服了一些克隆障碍， 成功地确定了两个几乎相同的增强子，一个位于 两个人C α基因中的每一个的大约10 kb 3'。 这些增强子含有与鼠源性DNA同源的191bp片段。 增强子3'aE（Hst2）。 他们希望研究人类 C α相关增强子，以进一步定位这些下游 区域，并评估它们的其他增强子，他们预测， 存在，并获得影响IgH基因的变异 在正常、免疫缺陷和恶性状态中表达。
英文摘要
The investigator's group has surmounted some cloning barriers and has succeeded in identifying two virtually identical enhancers, one located approximately 10 kb 3' of each of the two human C alpha genes. These enhancers contain a 191 bp segment of homology to the murine enhancer 3'aE (Hst2). They wish to study the regulation of the human C alpha associated enhancers, to further map these downstream regions and assess them for additional enhancers which they predict to be present, and to acquired variations that influence IgH gene expression in normal, immunodeficient and malignant states.
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