ANTI-ICAM-1 ANTIBODY TREATMENT AFTER MCA OCCLUSION

MCA 闭塞后抗 ICAM-1 抗体治疗

基本信息

  • 批准号:
    2655495
  • 负责人:
  • 金额:
    $ 22.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1995
  • 资助国家:
    美国
  • 起止时间:
    1995-02-01 至 1999-01-31
  • 项目状态:
    已结题

项目摘要

Ischemic brain injury evokes an endogenous brain parenchymal cell damage as well as an exogenous inflammatory response, which includes infiltration and accumulation of polymorphonuclear leukocytes and monocytes/macrophages, and microvascular proliferation. The migration and accumulation of neutrophils into the ischemic tissue after reperfusion is not only associated with tissue repair processes, but also may result in injury to potentially viable tissue. We propose to reduce ischemic cell damage after middle cerebral artery (MCA) occlusion in the rat by selectively blocking the intercellular adhesion molecule 1 (ICAM-1), a glycoprotein expressed on endothelial cells that facilitates leukocyte adhesion. Three specific aims and hypotheses will be tested. Aim 1: The effect of administration of a monoclonal antibody to the rat ICAM-1 on reducing ischemic cell damage will be investigated in rats subjected to transient (2 hours) and permanent MCA occlusion. Ischemic cell damage will be measured as a function of dose and time of antibody administration. Hypothesis: A monoclonal antibody reactive with the ICAM-1 glycoprotein reduces ischemic cell damage after transient MCA occlusion. Aim 2: We will measure the temporal profiles of expression of ICAM-1 and ICAM-1 mRNA in brain after transient MCA occlusion. Hypothesis: MCA occlusion results in an increase of both ICAM-1 message and protein in ischemic brain. Aim 3: Mechanisms by which the anti-ICAM-1 reactive antibody reduces ischemic cell damage will be investigated. 3(a): We will measure and correlate the temporal profile of the extent of neutrophil infiltration into the ischemic tissue with ischemic cell damage. Hypothesis: Anti-ICAM-1 antibody causes a reduction of neutrophils in the ischemic tissue. Infiltration of neutrophils into the ischemic tissue precedes or is concomitant with ischemic cell damage, and contributes to ischemic cell damage after transient focal cerebral ischemia. We will perform quantitative autoradiographic measurements of local cerebral blood flow at time points after transient MCA occlusion. Hypothesis: Neutrophils may contribute to ischemic cell damage in reperfusion injury by reducing local cerebral blood flow (CBF) and extending the duration of ischemia. Our long term objective is to develop a therapeutic intervention (anti- ICAM-1 antibody) to be employed after the onset of ischemic stroke.
缺血性脑损伤引起内源性脑实质细胞损伤

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MICHAEL CHOPP其他文献

MICHAEL CHOPP的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MICHAEL CHOPP', 18)}}的其他基金

Vasculotide promotes cognitive improvement in rats with vascular dementia
Vasculotide 促进血管性痴呆大鼠的认知改善
  • 批准号:
    10605198
  • 财政年份:
    2019
  • 资助金额:
    $ 22.87万
  • 项目类别:
Diabetic stroke cardiac dysfunction; treatment with CD133+Exosomes
糖尿病中风心功能不全;
  • 批准号:
    10242634
  • 财政年份:
    2018
  • 资助金额:
    $ 22.87万
  • 项目类别:
miR-17-92 exosome treatment of stroke
miR-17-92 外泌体治疗中风
  • 批准号:
    8996733
  • 财政年份:
    2015
  • 资助金额:
    $ 22.87万
  • 项目类别:
miR-17-92 exosome treatment of stroke
miR-17-92 外泌体治疗中风
  • 批准号:
    8886032
  • 财政年份:
    2015
  • 资助金额:
    $ 22.87万
  • 项目类别:
MSCs Induce Brain Plasticity via tPA
间充质干细胞通过 tPA 诱导大脑可塑性
  • 批准号:
    8104726
  • 财政年份:
    2011
  • 资助金额:
    $ 22.87万
  • 项目类别:
MSCs Induce Brain Plasticity via tPA
间充质干细胞通过 tPA 诱导大脑可塑性
  • 批准号:
    8450131
  • 财政年份:
    2011
  • 资助金额:
    $ 22.87万
  • 项目类别:
MSCs Induce Brain Plasticity via tPA
间充质干细胞通过 tPA 诱导大脑可塑性
  • 批准号:
    8248705
  • 财政年份:
    2011
  • 资助金额:
    $ 22.87万
  • 项目类别:
MSCs Induce Brain Plasticity via tPA
间充质干细胞通过 tPA 诱导大脑可塑性
  • 批准号:
    8657975
  • 财政年份:
    2011
  • 资助金额:
    $ 22.87万
  • 项目类别:
Administration
行政
  • 批准号:
    7252236
  • 财政年份:
    2007
  • 资助金额:
    $ 22.87万
  • 项目类别:
Treatment of Neural Injury with MSCs
间充质干细胞治疗神经损伤
  • 批准号:
    7073312
  • 财政年份:
    2003
  • 资助金额:
    $ 22.87万
  • 项目类别:

相似海外基金

Development of non-contact autoradiography technology using magnetic field
利用磁场的非接触式放射自显影技术的开发
  • 批准号:
    19K15947
  • 财政年份:
    2019
  • 资助金额:
    $ 22.87万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging
用于体内放射自显影成像的超高分辨率脑 PET 扫描仪
  • 批准号:
    9791189
  • 财政年份:
    2018
  • 资助金额:
    $ 22.87万
  • 项目类别:
Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging
用于体内放射自显影成像的超高分辨率脑 PET 扫描仪
  • 批准号:
    10117728
  • 财政年份:
    2018
  • 资助金额:
    $ 22.87万
  • 项目类别:
Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging
用于体内放射自显影成像的超高分辨率脑 PET 扫描仪
  • 批准号:
    10237144
  • 财政年份:
    2018
  • 资助金额:
    $ 22.87万
  • 项目类别:
Ultra High Resolution Brain PET Scanner for in-vivo Autoradiography Imaging
用于体内放射自显影成像的超高分辨率脑 PET 扫描仪
  • 批准号:
    10436281
  • 财政年份:
    2018
  • 资助金额:
    $ 22.87万
  • 项目类别:
Development of autoradiography technique capable of sequential imaging -Toward visualization of radioactive cesium dynamics in botanical bodies-
开发能够连续成像的放射自显影技术 -实现植物体中放射性铯动力学的可视化 -
  • 批准号:
    17K05109
  • 财政年份:
    2017
  • 资助金额:
    $ 22.87万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
application of high resolution arufa-autoradiography for analysing micro-distribution of B-compund in tissues and its BNCT effects
应用高分辨率阿鲁法放射自显影分析B化合物在组织中的微观分布及其BNCT效应
  • 批准号:
    26670557
  • 财政年份:
    2014
  • 资助金额:
    $ 22.87万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Visualization of the change in pain by the autoradiography and calcium imaging in the brain and spinal cord
通过放射自显影和大脑和脊髓钙成像显示疼痛变化
  • 批准号:
    24659294
  • 财政年份:
    2012
  • 资助金额:
    $ 22.87万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Real-Time Digital Autoradiography System
实时数字放射自显影系统
  • 批准号:
    7794778
  • 财政年份:
    2010
  • 资助金额:
    $ 22.87万
  • 项目类别:
Digital Autoradiography of an Irradiated Fuel Pellet
辐照燃料颗粒的数字放射自显影
  • 批准号:
    370568-2008
  • 财政年份:
    2008
  • 资助金额:
    $ 22.87万
  • 项目类别:
    University Undergraduate Student Research Awards
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了