MICROWAVE IMAGING FOR USE IN NON INVASIVE THERMOMETRY

用于无创测温的微波成像

• 批准号: 2009941
• 负责人: PAUL M MEANEY
• 金额: $ 10万
• 依托单位: MICROWAVE IMAGING SYSTEM TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2009941
• 关键词: biomedical equipment development; clinical biomedical equipment; imaging /visualization /scanning; microwave radiation; noninvasive diagnosis; phantom model; thermometry

Non-invasive electromagnetic imaging has been hypothesized as an inexpensive modality for reconstructing tissue temperature distributions via differencing techniques due to strong temperature dependence of tissue electrical properties. For example, the conductivity of high water content tissues varies 1 to 2% per degrees C depending on the operating frequency used. Despite the phenomenological advantages of microwave imaging for temperature sensing, most efforts have been hampered by an inability to reconstruct quantitative images of tissue properties from which differencing techniques can be applied to estimate temperature distributions. Our current system has achieved quantitative reconstructed images of material electrical properties in laboratory scale experiments with additional tests demonstrating excellent correlation between material electrical properties and temperature in relatively simplified experimental configurations. The primary objective of t his Phase I effort will be to demonstrate the feasibility of several key aspects of an approach to realizing a clinically-viable medical microwave imaging system. Specifically, the ability to image with a fixed array transceiver system utilizing a specially-designed illumination chamber housing will be assessed. Technical success of the Phase I feasibility study will be judged on whether 1 degrees C temperature discrimination on a 1 cm spatial scale across a tissue equivalent phantom region of 30 cm in size can be achieved using the proposed methodology. PROPOSED COMMERCIAL APPLICATION: The primary application of the proposed microwave imaging system will be non-invasive monitoring of temperature field distributions during thermally-based medical procedures such as hyperthermia treatment of cancer by exploiting the strong temperature dependence of tissue electrical properties.

无创电磁成像已经被假设为一种 用于重建组织温度的廉价方式 由于强温度通过差分技术进行的分布 对组织电学性质的依赖性。例如， 高含水率组织的电导率每度变化1%到2% C取决于使用的工作频率。尽管 微波成像测量温度的现象学优势 意识到，大多数努力都受到了无法 重建组织特性的定量图像 差分法可以用来估计温度。 分配。我们目前的制度已经实现了量化 实验室中材料电学性质的重建图像 通过附加测试进行的规模实验显示了出色的性能 材料电学性能与温度的关系 相对简化的实验配置。初级阶段 第一阶段工作的目标将是证明 实现一种方法的几个关键方面的可行性 临床可行的医用微波成像系统。具体地说， 能够使用固定阵列收发器系统进行图像处理 将对专门设计的照明室外壳进行评估。 第一阶段可行性研究的技术成功与否将根据 在1厘米的空间尺度上是否存在1摄氏度的温度分辨率 在大小为30厘米的组织等效体模区域上可以 使用建议的方法实现。 拟议的商业应用： 建议的微波成像系统将无创监测 基于热的医疗过程中的温度场分布 通过利用热疗治疗癌症等程序 组织电学性质强烈的温度依赖性。