Microwave Imaging for Neoadjuvant Chemotherapy Monitoring

用于新辅助化疗监测的微波成像

• 批准号: 9251651
• 负责人: PAUL M MEANEY
• 金额: $ 74.61万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9251651
• 关键词: Academic Medical Centers; Adipose tissue; Algorithms; Attention; Breast; Clinic; Clinical; Clinical Research; Community Healthcare; Computer software; Coupling; Data; Diagnostic; Electronics; Engineering; Enrollment; Ensure; Evaluation; Frequencies; Goals; Image; Imaging Techniques; Imaging technology; Infusion procedures; Left; Lighting; Link; Liquid substance; Magnetic Resonance Imaging; Malignant Neoplasms; Measurement; Medical Oncology; Modification; Monitor; Motor; Neoadjuvant Therapy; Noise; Normal tissue morphology; Optics; Outcome; Pathologic; Patient Monitoring; Patients; Pilot Projects; Process; Property; Pump; Recovery; Research; Scanning; Site; Specificity; Speed; Surface; System; Techniques; Technology; Three-Dimensional Image; Time; TimeLine; Translating; base; breast imaging; breast scan; chemotherapy; clinical care; clinical research site; cost; data acquisition; design; dielectric property; experimental study; graphical user interface; image reconstruction; imaging modality; imaging study; imaging system; improved; industry partner; innovation; interest; malignant breast neoplasm; microwave electromagnetic radiation; portability; predicting response; prototype; public health relevance; reconstruction; research clinical testing; response; standard of care; tomography; treatment response; tumor; tumor progression; user-friendly

DESCRIPTION (provided by applicant): Microwave tomographic imaging of the breast has successfully advanced to initial clinical testing for monitoring treatment response to breast cancer neoadjuvant chemotherapy. The Dartmouth microwave imaging team has performed over 500 breast exams in both diagnostic and therapy monitoring settings which have demonstrated that recovered images of the endogenous dielectric properties are highly specific to distinguishing tumor from normal tissue, and to following response to therapy. In initial therapy monitoring patient studies, results indicate that images acquired as early as 30 days after the start of treatment correlate well with pathological outcomes. In this project, the Dartmouth microwave imaging group will team with General Electric's (GE's) Global Research Center to further refine and optimize the current technology as an important step towards translating it into the clinic. Design modifications are conceived to advance the technology using best engineering practices and to prepare it for a two center imaging study. Because the current system utilizes a modest amount of measurement data and has the lowest computational requirements of any microwave tomographic system world-wide, the overall costs will remain low and system configuration simplicity will be preserved. Designing for a second site will require a significant level of additional rigor be applied to the current system to ensure that it an be operated reliably and efficiently at a remote site. Refinements will incorporate previously proven spatial prior techniques designed to isolate the dielectric property recovery in pre-determined zones - specifically in tumor, and fibroglandular and adipose tissues without unduly biasing the final images. In addition, multi-frequency imaging methods will be refined and added to increase the spectral content of the recovered data and subsequently to improve the specificity of the reconstruction process. Each of these innovations will be incorporated into the new compact and portable design where special attention has been paid to clinical workflow requirements.

描述（由申请人提供）：乳腺微波断层成像已成功进入初步临床试验，用于监测乳腺癌新辅助化疗的治疗反应。达特茅斯微波成像团队在诊断和治疗监测环境中进行了500多次乳腺检查，这些检查表明，内源性介电特性的恢复图像对于区分肿瘤和正常组织以及对治疗的后续反应具有高度特异性。在最初的治疗监测患者研究中，结果表明，早在治疗开始后30天获得的图像与病理结果相关。在这个项目中，达特茅斯微波成像小组将与通用电气（GE）全球研究中心合作，进一步完善和优化当前的技术，作为将其转化为临床的重要一步。设计修改旨在使用最佳工程实践推进技术，并为双中心成像研究做好准备。因为当前系统利用适度量的测量数据并且具有世界范围内的任何微波层析成像系统的最低计算要求，所以总体成本将保持较低并且系统配置将保持简单性。为第二个站点进行设计将需要对当前系统进行更严格的严格要求，以确保该系统在远程站点能够可靠和有效地运行。改进将纳入先前已证明的空间先验技术，旨在隔离预定区域中的介电特性恢复-特别是在肿瘤，纤维腺和脂肪组织中，而不会过度偏置最终图像。此外，将改进和增加多频成像方法，以增加恢复数据的频谱内容，从而提高重建过程的特异性。每一项创新都将被纳入新的紧凑和便携式设计中，特别关注临床工作流程的要求。