Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
基本信息
- 批准号:10569628
- 负责人:
- 金额:$ 58.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAnatomyBenignBindingBiomedical EngineeringBreastBreast Cancer DetectionBreast Magnetic Resonance ImagingClinicalClinical ResearchClinical Trials DesignCustomDataDevelopmentDiagnosisDiagnosticDiagnostic SpecificityDiffusion Magnetic Resonance ImagingElectronicsFundingFutureGadoliniumGoalsHealthcare SystemsImageImaging TechniquesInjectionsMagnetic Resonance ImagingMalignant NeoplasmsMammary Gland ParenchymaMapsMeasurementNoiseOutcomeParticipantPatientsPerformancePhysicsPrincipal InvestigatorProceduresProcessPropertyRadiology SpecialtyRecoveryResearchResolutionRotationSafetySerial Magnetic Resonance ImagingSignal TransductionSpecificityStructureSystemTechnologyTestingTimeTissue imagingTissuesTranslationsUncertaintyWaterWomanbreast exambreast imagingbreast lesionclinical imagingcontrast enhancedcostdensitydesigndiagnostic accuracyelectrical propertyexperienceexperimental studyimage reconstructionimaging platformimaging potentialimaging propertiesimaging systemimprovedimproved outcomeindustry partnerinnovationinterestmalignant breast neoplasmmicrowave electromagnetic radiationmicrowave imagingmultimodalityprototypereconstructionresearch clinical testingsecondary endpointstandard of caretissue mappingtumor microenvironment
项目摘要
PROJECT SUMMARY/ABSTRACT
This Academic-Industry Partnership, AIP, proposal (PAR-18-009) will develop and evaluate an innovative
multi-modality breast imaging platform that performs simultaneous Microwave and Magnetic Resonance
Imaging (sMMRI). It incorporates a multiple-principal-investigator (multi-PI) research plan and AIP governance
structure that leverages expertise from Dartmouth, Dartmouth-Hitchcock, and Quality Electrodynamics (QED)
in biomedical engineering, MRI and microwave physics, computational inversion and estimation, and breast
radiology. Industry partner QED will apply its extensive experience in design and implementation of specialized
MRI coils that will be fully integrated and compatible with Dartmouth’s microwave imaging (MI) electronics and
in-bore antenna array. To date, we have demonstrated technical feasibility of sMMRI and have realized a
prototype that has delivered the first successful clinical breast exams. While potential promise of sMMRI has
been suggested, especially in terms of acquiring quantitatively-accurate spatial maps of tissue electrical
properties (i.e. permittivity and conductivity), further technical innovations are needed and more experience
with sMMRI, both technically and clinically, is required to develop the technology sufficiently for a full clinical
evaluation. To advance and optimize sMMRI of the breast while also increasing our understanding of its clinical
potential, we propose to (1) develop and integrate MRI (receive) coils with MI antenna arrays to optimize MRI
and MI image quality, and breast coverage during an sMMRI clinical breast exam, (2) estimate breast tissue
electrical properties from sMMRI data by encoding MRI anatomical priors into the 3D reconstruction process,
and (3) complete phantom and clinical breast imaging experiments with sMMRI to evaluate and optimize the
proposed technical developments, and to conduct a clinical study in women with undiagnosed breast
abnormalities to test the hypothesis that sMMRI improves the specificity of breast MR alone. If the studies we
propose are successful, we will have realized an innovative multi-modality breast imaging platform that is ready
for involvement in larger statistically-powered clinical studies of its diagnostic performance in the future.
项目总结/文摘
项目成果
期刊论文数量(0)
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PAUL M MEANEY其他文献
PAUL M MEANEY的其他文献
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{{ truncateString('PAUL M MEANEY', 18)}}的其他基金
Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
- 批准号:
9973579 - 财政年份:2020
- 资助金额:
$ 58.84万 - 项目类别:
Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
- 批准号:
10338160 - 财政年份:2020
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Imaging for Neoadjuvant Chemotherapy Monitoring
用于新辅助化疗监测的微波成像
- 批准号:
9251651 - 财政年份:2015
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Imaging for Neoadjuvant Chemotherapy Monitoring
用于新辅助化疗监测的微波成像
- 批准号:
9040121 - 财政年份:2015
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Thermal Monitoring for Breast Hyperthermia
乳房热疗的微波热监测
- 批准号:
6443777 - 财政年份:1997
- 资助金额:
$ 58.84万 - 项目类别:
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