Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities

同时微波和 MR 成像可改善乳房异常的诊断

• 批准号: 10569628
• 负责人: PAUL M MEANEY
• 金额: $ 58.84万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569628
• 关键词: 3-Dimensional; Address; Anatomy; Benign; Binding; Biomedical Engineering; Breast; Breast Cancer Detection; Breast Magnetic Resonance Imaging; Clinical; Clinical Research; Clinical Trials Design; Custom; Data; Development; Diagnosis; Diagnostic; Diagnostic Specificity; Diffusion Magnetic Resonance Imaging; Electronics; Funding; Future; Gadolinium; Goals; Healthcare Systems; Image; Imaging Techniques; Injections; Magnetic Resonance Imaging; Malignant Neoplasms; Mammary Gland Parenchyma; Maps; Measurement; Noise; Outcome; Participant; Patients; Performance; Physics; Principal Investigator; Procedures; Process; Property; Radiology Specialty; Recovery; Research; Resolution; Rotation; Safety; Serial Magnetic Resonance Imaging; Signal Transduction; Specificity; Structure; System; Technology; Testing; Time; Tissue imaging; Tissues; Translations; Uncertainty; Water; Woman; breast exam; breast imaging; breast lesion; clinical imaging; contrast enhanced; cost; density; design; diagnostic accuracy; electrical property; experience; experimental study; image reconstruction; imaging platform; imaging potential; imaging properties; imaging system; improved; improved outcome; industry partner; innovation; interest; malignant breast neoplasm; microwave electromagnetic radiation; microwave imaging; multimodality; prototype; reconstruction; research clinical testing; secondary endpoint; standard of care; tissue mapping; tumor microenvironment

PROJECT SUMMARY/ABSTRACT This Academic-Industry Partnership, AIP, proposal (PAR-18-009) will develop and evaluate an innovative multi-modality breast imaging platform that performs simultaneous Microwave and Magnetic Resonance Imaging (sMMRI). It incorporates a multiple-principal-investigator (multi-PI) research plan and AIP governance structure that leverages expertise from Dartmouth, Dartmouth-Hitchcock, and Quality Electrodynamics (QED) in biomedical engineering, MRI and microwave physics, computational inversion and estimation, and breast radiology. Industry partner QED will apply its extensive experience in design and implementation of specialized MRI coils that will be fully integrated and compatible with Dartmouth’s microwave imaging (MI) electronics and in-bore antenna array. To date, we have demonstrated technical feasibility of sMMRI and have realized a prototype that has delivered the first successful clinical breast exams. While potential promise of sMMRI has been suggested, especially in terms of acquiring quantitatively-accurate spatial maps of tissue electrical properties (i.e. permittivity and conductivity), further technical innovations are needed and more experience with sMMRI, both technically and clinically, is required to develop the technology sufficiently for a full clinical evaluation. To advance and optimize sMMRI of the breast while also increasing our understanding of its clinical potential, we propose to (1) develop and integrate MRI (receive) coils with MI antenna arrays to optimize MRI and MI image quality, and breast coverage during an sMMRI clinical breast exam, (2) estimate breast tissue electrical properties from sMMRI data by encoding MRI anatomical priors into the 3D reconstruction process, and (3) complete phantom and clinical breast imaging experiments with sMMRI to evaluate and optimize the proposed technical developments, and to conduct a clinical study in women with undiagnosed breast abnormalities to test the hypothesis that sMMRI improves the specificity of breast MR alone. If the studies we propose are successful, we will have realized an innovative multi-modality breast imaging platform that is ready for involvement in larger statistically-powered clinical studies of its diagnostic performance in the future.

项目总结/文摘