Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
基本信息
- 批准号:10569628
- 负责人:
- 金额:$ 58.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-02-15 至 2025-02-28
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAnatomyBenignBindingBiomedical EngineeringBreastBreast Cancer DetectionBreast Magnetic Resonance ImagingClinicalClinical ResearchClinical Trials DesignCustomDataDevelopmentDiagnosisDiagnosticDiagnostic SpecificityDiffusion Magnetic Resonance ImagingElectronicsFundingFutureGadoliniumGoalsHealthcare SystemsImageImaging TechniquesInjectionsMagnetic Resonance ImagingMalignant NeoplasmsMammary Gland ParenchymaMapsMeasurementNoiseOutcomeParticipantPatientsPerformancePhysicsPrincipal InvestigatorProceduresProcessPropertyRadiology SpecialtyRecoveryResearchResolutionRotationSafetySerial Magnetic Resonance ImagingSignal TransductionSpecificityStructureSystemTechnologyTestingTimeTissue imagingTissuesTranslationsUncertaintyWaterWomanbreast exambreast imagingbreast lesionclinical imagingcontrast enhancedcostdensitydesigndiagnostic accuracyelectrical propertyexperienceexperimental studyimage reconstructionimaging platformimaging potentialimaging propertiesimaging systemimprovedimproved outcomeindustry partnerinnovationinterestmalignant breast neoplasmmicrowave electromagnetic radiationmicrowave imagingmultimodalityprototypereconstructionresearch clinical testingsecondary endpointstandard of caretissue mappingtumor microenvironment
项目摘要
PROJECT SUMMARY/ABSTRACT
This Academic-Industry Partnership, AIP, proposal (PAR-18-009) will develop and evaluate an innovative
multi-modality breast imaging platform that performs simultaneous Microwave and Magnetic Resonance
Imaging (sMMRI). It incorporates a multiple-principal-investigator (multi-PI) research plan and AIP governance
structure that leverages expertise from Dartmouth, Dartmouth-Hitchcock, and Quality Electrodynamics (QED)
in biomedical engineering, MRI and microwave physics, computational inversion and estimation, and breast
radiology. Industry partner QED will apply its extensive experience in design and implementation of specialized
MRI coils that will be fully integrated and compatible with Dartmouth’s microwave imaging (MI) electronics and
in-bore antenna array. To date, we have demonstrated technical feasibility of sMMRI and have realized a
prototype that has delivered the first successful clinical breast exams. While potential promise of sMMRI has
been suggested, especially in terms of acquiring quantitatively-accurate spatial maps of tissue electrical
properties (i.e. permittivity and conductivity), further technical innovations are needed and more experience
with sMMRI, both technically and clinically, is required to develop the technology sufficiently for a full clinical
evaluation. To advance and optimize sMMRI of the breast while also increasing our understanding of its clinical
potential, we propose to (1) develop and integrate MRI (receive) coils with MI antenna arrays to optimize MRI
and MI image quality, and breast coverage during an sMMRI clinical breast exam, (2) estimate breast tissue
electrical properties from sMMRI data by encoding MRI anatomical priors into the 3D reconstruction process,
and (3) complete phantom and clinical breast imaging experiments with sMMRI to evaluate and optimize the
proposed technical developments, and to conduct a clinical study in women with undiagnosed breast
abnormalities to test the hypothesis that sMMRI improves the specificity of breast MR alone. If the studies we
propose are successful, we will have realized an innovative multi-modality breast imaging platform that is ready
for involvement in larger statistically-powered clinical studies of its diagnostic performance in the future.
项目概要/摘要
该学术-工业合作伙伴关系 (AIP) 提案 (PAR-18-009) 将开发和评估创新
同时执行微波和磁共振的多模态乳腺成像平台
成像(sMMRI)。它包含多位主要研究者 (multi-PI) 研究计划和 AIP 治理
利用达特茅斯、达特茅斯-希区柯克和 Quality Electrodynamics (QED) 专业知识的结构
生物医学工程、MRI 和微波物理、计算反演和估计以及乳腺
放射学。行业合作伙伴 QED 将运用其在专业化设计和实施方面的丰富经验
MRI 线圈将与达特茅斯的微波成像 (MI) 电子设备完全集成并兼容
孔内天线阵列。迄今为止,我们已经证明了sMMRI的技术可行性,并实现了
原型机首次成功进行了临床乳房检查。虽然 sMMRI 的潜在前景
被建议,特别是在获取组织电的定量准确的空间图方面
性质(即介电常数和电导率),需要进一步的技术创新和更多的经验
sMMRI 在技术上和临床上都需要充分开发该技术以进行全面的临床
评估。推进和优化乳腺 sMMRI,同时增加我们对其临床的了解
潜力,我们建议 (1) 开发 MRI(接收)线圈并将其与 MI 天线阵列集成,以优化 MRI
和 MI 图像质量以及 sMMRI 临床乳房检查期间的乳房覆盖范围,(2) 估计乳房组织
通过将 MRI 解剖先验编码到 3D 重建过程中,从 sMMRI 数据中获得电特性,
(3) 使用 sMMRI 完成模型和临床乳腺成像实验,以评估和优化
提出技术发展建议,并对未确诊乳房的女性进行临床研究
异常来检验 sMMRI 单独提高乳腺 MR 特异性的假设。如果研究我们
如果建议成功,我们将实现一个已准备就绪的创新多模态乳腺成像平台
参与未来对其诊断性能的更大规模的统计临床研究。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
PAUL M MEANEY其他文献
PAUL M MEANEY的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('PAUL M MEANEY', 18)}}的其他基金
Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
- 批准号:
9973579 - 财政年份:2020
- 资助金额:
$ 58.84万 - 项目类别:
Simultaneous Microwave and MR Imaging for Improved Diagnosis of Breast Abnormalities
同时微波和 MR 成像可改善乳房异常的诊断
- 批准号:
10338160 - 财政年份:2020
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Imaging for Neoadjuvant Chemotherapy Monitoring
用于新辅助化疗监测的微波成像
- 批准号:
9251651 - 财政年份:2015
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Imaging for Neoadjuvant Chemotherapy Monitoring
用于新辅助化疗监测的微波成像
- 批准号:
9040121 - 财政年份:2015
- 资助金额:
$ 58.84万 - 项目类别:
Microwave Thermal Monitoring for Breast Hyperthermia
乳房热疗的微波热监测
- 批准号:
6443777 - 财政年份:1997
- 资助金额:
$ 58.84万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 58.84万 - 项目类别:
Research Grant














{{item.name}}会员




