Microwave Thermal Monitoring for Breast Hyperthermia

乳房热疗的微波热监测

• 批准号: 6443777
• 负责人: PAUL M MEANEY
• 金额: $ 39.04万
• 依托单位: MICROWAVE IMAGING SYSTEM TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443777
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasms; clinical biomedical equipment; computer program /software; human tissue; hyperthermia therapy; imaging /visualization /scanning; microwave radiation; noninvasive diagnosis; patient monitoring device; phantom model; thermometry

DESCRIPTION (Provided by Applicant): We propose to develop a tank-based microwave thermal imaging system for monitoring temperature profiles in breast tissue during hyperthermia treatments. Based on encouraging Phase II clinical trials for breast cancer treatment, complete response rates were shown to improve significantly when hyperthermia was added to radiation treatment protocols. This work will draw on the feasibility study conducted during Phase I where we demonstrated the capability of quantitatively monitoring temperatures to within 1 degree Celcius and a spatial resolution of 1 cm. Efforts by the Dartmouth College microwave imaging research group to develop a clinical breast cancer detection system has also established the feasibility of in vivo microwave breast imaging using a water-coupled interface in the clinical environment. The key components of Phase II will include refining the prototype clinical patient interface and integrating it with a scanned focused ultrasound hyperthermia device. A primary objective of Phase II will be to develop a clinical prototype system where data can be collected for image reconstruction at several vertical positions in less than one minute with quantitative difference images being available as treatment feedback information within 2 minutes after collection of each data set. Initial overall performance assessments will be conducted using phantom and ex vivo experimental configurations. PROPOSED COMMERCIAL APPLICATION: Breast cancer treatment remains an important health care problem. This system will facilitate the use of adjuvant hyperthermia by providing a low-cost noninvasive monitoring technique. It addresses previous difficulties associated with noninvasive temperature detection by providing near real-time data acquisition and expedited image reconstruction along with fabrication of an effective patient interface. It will set the stage for future treatment/monitoring systems targeting other anatomical sites.

描述（由申请人提供）：我们建议开发一种基于坦克的 用于监测乳房温度分布的微波热成像系统 热疗期间的组织。基于令人鼓舞的II期临床 乳腺癌治疗试验显示，完全缓解率 当放射治疗中加入热疗时，改善显着 协议。这项工作将借鉴阶段期间进行的可行性研究 I 我们展示了定量监测的能力 温度误差在 1 摄氏度以内，空间分辨率为 1 厘米。 达特茅斯学院微波成像研究小组努力开发一种 临床乳腺癌检测系统也确立了可行性 使用水耦合界面进行体内微波乳腺成像 临床环境。第二阶段的关键组成部分将包括完善 原型临床患者界面并将其与扫描聚焦集成 超声波热疗装置。第二阶段的主要目标是 开发一个临床原型系统，可以收集图像数据 在不到一分钟的时间内在多个垂直位置进行重建 定量差异图像可作为治疗反馈 收集每个数据集后 2 分钟内的信息。初始整体 将使用体模和离体进行性能评估 实验配置。 拟议的商业应用：乳腺癌治疗仍然是一个重要的医疗保健问题。 该系统将通过提供低成本的无创监测技术来促进辅助热疗的使用。 它通过提供近乎实时的数据采集和加速图像重建以及有效的患者界面的制造，解决了以前与无创温度检测相关的困难。 它将为未来针对其他解剖部位的治疗/监测系统奠定基础。