Microwave Thermal Monitoring for Breast Hyperthermia

乳房热疗的微波热监测

• 批准号: 6443777
• 负责人: PAUL M MEANEY
• 金额: $ 39.04万
• 依托单位: MICROWAVE IMAGING SYSTEM TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6443777
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasms; clinical biomedical equipment; computer program /software; human tissue; hyperthermia therapy; imaging /visualization /scanning; microwave radiation; noninvasive diagnosis; patient monitoring device; phantom model; thermometry

DESCRIPTION (Provided by Applicant): We propose to develop a tank-based microwave thermal imaging system for monitoring temperature profiles in breast tissue during hyperthermia treatments. Based on encouraging Phase II clinical trials for breast cancer treatment, complete response rates were shown to improve significantly when hyperthermia was added to radiation treatment protocols. This work will draw on the feasibility study conducted during Phase I where we demonstrated the capability of quantitatively monitoring temperatures to within 1 degree Celcius and a spatial resolution of 1 cm. Efforts by the Dartmouth College microwave imaging research group to develop a clinical breast cancer detection system has also established the feasibility of in vivo microwave breast imaging using a water-coupled interface in the clinical environment. The key components of Phase II will include refining the prototype clinical patient interface and integrating it with a scanned focused ultrasound hyperthermia device. A primary objective of Phase II will be to develop a clinical prototype system where data can be collected for image reconstruction at several vertical positions in less than one minute with quantitative difference images being available as treatment feedback information within 2 minutes after collection of each data set. Initial overall performance assessments will be conducted using phantom and ex vivo experimental configurations. PROPOSED COMMERCIAL APPLICATION: Breast cancer treatment remains an important health care problem. This system will facilitate the use of adjuvant hyperthermia by providing a low-cost noninvasive monitoring technique. It addresses previous difficulties associated with noninvasive temperature detection by providing near real-time data acquisition and expedited image reconstruction along with fabrication of an effective patient interface. It will set the stage for future treatment/monitoring systems targeting other anatomical sites.

描述（由申请人提供）：我们建议开发一种基于坦克的 用于监测乳房温度分布的微波热成像系统 在高温治疗过程中。基于鼓励II期临床 乳腺癌治疗的临床试验中，完全缓解率显示， 在放射治疗中加入热疗后， 协议.这项工作将借鉴第三阶段进行的可行性研究， 在那里我们展示了定量监测 温度控制在1摄氏度以内，空间分辨率为1厘米。 达特茅斯学院微波成像研究小组努力开发一种 临床乳腺癌检测系统也建立了可行性， 在体内微波乳房成像中使用水耦合界面 临床环境第二阶段的主要组成部分将包括完善 原型临床患者界面，并将其与扫描聚焦 超声波热疗装置第二阶段的主要目标是 开发一个临床原型系统，可以收集数据进行成像 在不到一分钟的时间内在几个垂直位置进行重建， 定量差异图像可用作治疗反馈 在收集每个数据集后2分钟内提供信息。初始总 将使用体模和离体进行性能评估 实验配置 建议的商业应用：乳腺癌治疗仍然是一个重要的医疗保健问题。 该系统将通过提供低成本的非侵入性监测技术来促进辅助热疗的使用。 它解决了以前的困难与非侵入性的温度检测提供近实时数据采集和加快图像重建沿着制造一个有效的病人接口。 它将为未来针对其他解剖部位的治疗/监测系统奠定基础。