REGENERATION OF CD4 LYMPHOCYTES

CD4 淋巴细胞的再生

• 批准号: 2431624
• 负责人: DORIS B TSE
• 金额: $ 8.38万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2431624
• 关键词: AIDS therapy; CD4 molecule; DNA; HIV infections; antiviral agents; apoptosis; biomarker; cell adhesion molecules; cell cycle; cell proliferation; clinical research; cyclins; cytokine; cytokine receptors; flow cytometry; helper T lymphocyte; human subject; receptor expression; virus load

DESCRIPTION (adapted from applicant's abstract): The primary aim of this project is to determine if (i) apoptosis of the cycling pool, or (ii) cell cycle arrest is contributing to the failure of CD4 cells to regenerate, and (iii) identify the potential cellular lesions associated therewith. Towards this goal, the investigators will focus on longitudinal samples obtained during the acute phase of anti-viral therapy. They will determine by FACS analysis the presence or intensity of cytokine receptors, adhesion molecules, apoptotic markers, DNA content, and restriction point-related cyclins on Ki67-expressing CD4 cells and their ex vivo cytokine response. By comparing the data obtained at time points which display different kinetics of CD4 lymphocyte regeneration, they hope to better define the conditions which potentiate or inhibit peripheral CD4 expansion.

描述（改编自申请人摘要）：本研究的主要目的