CEPHALIC PHASE REFLEX PATHS IN THE DORSAL VAGAL COMPLEX
背迷走神经复合体中的头相反射路径
基本信息
- 批准号:2391130
- 负责人:
- 金额:$ 2.62万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1996
- 资助国家:美国
- 起止时间:1996-04-01 至 1998-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The principles governing the operation of the intricate neural circuits in
the brainstem are enigmatic, despite their vital importance in the control
of virtually every major homeostatic function in the body. In the
brainstem, the nucleus tractus solitarius (NTS) and the dorsal motor
nucleus of the vagus (DMV) are of paramount importance. The NTS processes
afferent information from vast regions of the body, communicates with
other brainstem and forebrain structures, and contains a myriad of
neurotransmitters. The DMV is the primary channel through which the NTS
sends parasympathetic signals out to the major organ systems. To gain
insight into how these two nuclei integrate information representing
diverse sensory modalities, this study will focus on the relationship
between a subset of the afferents to NTS, those originating from the oral
cavity, and a subset of the efferents from DMV, those directed to the
subdiaphragmatic viscera. Oral sensory stimulation modulates a variety of
gastrointestinal functions by activating the parasympathetic nervous
system. These "cephalic phase reflexes" may be important for priming and
optimizing digestive processes and nutrient metabolism. The central
circuitry governing these reflexes has not been characterized.
Understanding this circuitry is important in itself because of its
potential involvement in disorders of digestive and metabolic functions.
Oral sensory information ascends directly to rostral NTS, and modulates
enteric functions through the DMV. The long term objective of this project
is to characterize the connections linking rostral NTS to vagal
motoneurons projecting to subdiaphragmatic viscera. These connections may
contain the key to understanding how cephalic phase reflexes are organized
and controlled by the brainstem. Specific aims are: (1) to locate vagal
motoneurons activated either by oral sensory afferents in the solitary
tract, or by rostral NTS neurons, and (2) to map the NTS presynaptic
inputs to each of these neurons. Comparison of these maps will indicate if
vagal output is under the control of discrete combinations of sensory
inputs.
控制复杂神经回路运作的原理,
脑干是神秘的,尽管它们在控制
几乎所有主要的自我平衡功能。在
脑干、孤束核和背侧运动
迷走神经核(DMV)是最重要的。NTS进程
来自身体广大区域的传入信息,
其他脑干和前脑结构,并包含无数的
神经传递素车管所是NTS的主要渠道
向主要器官系统发送副交感神经信号。获得
深入了解这两个核心如何整合信息,
不同的感觉方式,这项研究将集中在关系
在NTS的传入神经的一个子集之间,那些起源于口腔的
腔,和一个子集的传出从DMV,那些直接向
脑下内脏口腔感觉刺激调节多种
胃肠道功能通过激活副交感神经
系统这些“头相反射”对于启动和
优化消化过程和营养代谢。中央
控制这些反射的电路尚未被表征。
了解这种电路本身就很重要,因为它
可能涉及消化和代谢功能紊乱。
口腔感觉信息直接上升到喙侧NTS,
肠道功能通过车管所本项目的长期目标
是为了表征连接喙侧NTS和迷走神经的连接,
运动神经元投射到脑下内脏。这些连接可以
包含理解头相反射如何组织的关键
由脑干控制具体目的是:(1)定位迷走神经
运动神经元激活或口腔感觉传入在孤立的
束,或通过吻侧NTS神经元,和(2)映射NTS突触前
输入到这些神经元。这些地图的比较将表明,
迷走神经输出受感觉神经的离散组合的控制,
输入。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Slice blotting: a method for detecting the release of immunoreactive substances from living brain tissue.
切片印迹:一种检测活体脑组织释放免疫反应物质的方法。
- DOI:10.1016/s0165-0270(99)00074-6
- 发表时间:1999
- 期刊:
- 影响因子:3
- 作者:Lowe,G
- 通讯作者:Lowe,G
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
GRAEME LOWE其他文献
GRAEME LOWE的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('GRAEME LOWE', 18)}}的其他基金
相似海外基金
CAREER: Large-Scale Computational Neuroimaging of Brain Electrical Activity
职业:脑电活动的大规模计算神经成像
- 批准号:
0955260 - 财政年份:2010
- 资助金额:
$ 2.62万 - 项目类别:
Standard Grant
Commercial testing of a physiologically based theory of oscillatory brain electrical activity in anaesthesia monitoring
麻醉监测中振荡脑电活动生理学理论的商业测试
- 批准号:
nhmrc : 448609 - 财政年份:2008
- 资助金额:
$ 2.62万 - 项目类别:
NHMRC Development Grants
Brain electrical activity on temporal discrimination in rats.
脑电活动对大鼠时间辨别的影响。
- 批准号:
16530471 - 财政年份:2004
- 资助金额:
$ 2.62万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
ITR: High-Resolution Cortical Imaging of Brain Electrical Activity
ITR:脑电活动的高分辨率皮质成像
- 批准号:
0411898 - 财政年份:2004
- 资助金额:
$ 2.62万 - 项目类别:
Standard Grant
Verification of a theoretical model of the dynamical genesis of brain electrical activity
脑电活动动力学发生理论模型的验证
- 批准号:
ARC : DP0209218 - 财政年份:2002
- 资助金额:
$ 2.62万 - 项目类别:
Discovery Projects
ITR: High-Resolution Cortical Imaging of Brain Electrical Activity
ITR:脑电活动的高分辨率皮质成像
- 批准号:
0218736 - 财政年份:2002
- 资助金额:
$ 2.62万 - 项目类别:
Standard Grant
Verification of a theoretical model of the dynamical genesis of brain electrical activity
脑电活动动力学发生理论模型的验证
- 批准号:
DP0209218 - 财政年份:2002
- 资助金额:
$ 2.62万 - 项目类别:
Discovery Projects
SLEEP DEPRIVATION EFFECTS ON VIGILANCE AND REGIONAL BRAIN ELECTRICAL ACTIVITY
睡眠剥夺对警觉性和区域脑电活动的影响
- 批准号:
6282077 - 财政年份:1997
- 资助金额:
$ 2.62万 - 项目类别:
Variability of brain electrical activity as a marker of schizophrenia
脑电活动的变异性作为精神分裂症的标志
- 批准号:
nhmrc : 920052 - 财政年份:1992
- 资助金额:
$ 2.62万 - 项目类别:
NHMRC Project Grants
Variability of brain electrical activity as a marker of schizophrenia
脑电活动的变异性作为精神分裂症的标志
- 批准号:
nhmrc : 900244 - 财政年份:1990
- 资助金额:
$ 2.62万 - 项目类别:
NHMRC Project Grants