BASAL GANGLIA AND WORKING MEMORY

基底神经节和工作记忆

• 批准号: 2521296
• 负责人: Vivek Prabhakaran
• 金额: $ 2.48万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-22 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2521296
• 关键词: basal ganglia; brain electrical activity; brain mapping; clinical research; functional magnetic resonance imaging; human subject; image processing; memory; neural information processing; neuroanatomy; space perception; verbal learning; visual perception

There is overwhelming lesion and physiological evidence in animals paralleled by focal lesions and clinical evidence in humans that suggests that the basal ganglia plays a key role in working memory. Paradoxically, imaging studies of working memory have failed to activate the basal ganglia. I have been able to show working memory activation within the basal ganglia. The present proposal builds on this pilot data in a systematic fashion. The goal of this project is to delineate areas within the basal ganglia that are important for working memory and to characterize this activation within a psychological construct. Two different aims will be followed to achieve this goal. The set of experiments proposed under specific aim 1 will utilize fMRI in order to identify neural substrates within the basal ganglia that are specific to different domains of working memory. If such neural substrates exist, then this supports the thesis that the striatum might be segregated in a domain-specific manner. The other issue that this study is aimed at resolving are the contributions of the basal ganglia to the central executive system of working memory or working memory general (WMG). This aspect of working memory is used in the widest range of cognitive performance and has been linked to reliable differences in reasoning abilities. The set of fMRI experiments proposed under specific aim 2 are aimed at identifying areas within the basal ganglia that are involved in central executive processes. The proposed study aims to identify discrete components involved in working memory within the basal ganglia that can be utilized to identify specific functional loss due to neuroanatomical lesions that occurs in clinical populations, such as in patients with Huntington's disease, Parkinson's disease, Schizophrenia, and Tourette's syndrome.

动物有压倒性的病变和生理证据 与人类的局灶性病变和临床证据并行 表明基底神经节在工作记忆中起关键作用。 矛盾的是，工作记忆的成像研究未能 激活基底神经节。 我已经能够显示工作记忆 基底神经节内的激活。 目前的提议以此为基础 以系统的方式进行飞行数据。 这个项目的目标是 划定基底神经节内的区域对于工作很重要 记忆并在心理中表征这种激活 构造。 将遵循两个不同的目标来实现这一目标。 在特定目标1下提出的一组实验将利用fMRI 为了识别基底神经节内的神经底物 特定于工作内存的不同领域。 如果这样的神经 存在底物，这支持了纹状体可能是 以域特异性方式隔离。 另一个问题 研究旨在解决基础神经节的贡献 工作记忆或工作记忆的中央执行系统 一般（WMG）。 工作记忆的这一方面最宽 认知表现范围，并与可靠 推理能力的差异。 fMRI实验集 根据特定目标2提出的旨在识别 参与中央执行程序的基底神经节。 这 拟议的研究旨在确定涉及的离散组件 基底神经节内的工作记忆 确定由于神经解剖病变引起的特定功能损失 发生在临床人群中，例如亨廷顿患者 疾病，帕金森氏病，精神分裂症和图雷特综合症。