BASAL GANGLIA AND WORKING MEMORY

基底神经节和工作记忆

• 批准号: 2521296
• 负责人: Vivek Prabhakaran
• 金额: $ 2.48万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-22 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2521296
• 关键词: basal ganglia; brain electrical activity; brain mapping; clinical research; functional magnetic resonance imaging; human subject; image processing; memory; neural information processing; neuroanatomy; space perception; verbal learning; visual perception

There is overwhelming lesion and physiological evidence in animals paralleled by focal lesions and clinical evidence in humans that suggests that the basal ganglia plays a key role in working memory. Paradoxically, imaging studies of working memory have failed to activate the basal ganglia. I have been able to show working memory activation within the basal ganglia. The present proposal builds on this pilot data in a systematic fashion. The goal of this project is to delineate areas within the basal ganglia that are important for working memory and to characterize this activation within a psychological construct. Two different aims will be followed to achieve this goal. The set of experiments proposed under specific aim 1 will utilize fMRI in order to identify neural substrates within the basal ganglia that are specific to different domains of working memory. If such neural substrates exist, then this supports the thesis that the striatum might be segregated in a domain-specific manner. The other issue that this study is aimed at resolving are the contributions of the basal ganglia to the central executive system of working memory or working memory general (WMG). This aspect of working memory is used in the widest range of cognitive performance and has been linked to reliable differences in reasoning abilities. The set of fMRI experiments proposed under specific aim 2 are aimed at identifying areas within the basal ganglia that are involved in central executive processes. The proposed study aims to identify discrete components involved in working memory within the basal ganglia that can be utilized to identify specific functional loss due to neuroanatomical lesions that occurs in clinical populations, such as in patients with Huntington's disease, Parkinson's disease, Schizophrenia, and Tourette's syndrome.

动物身上有大量的病变和生理证据 与人类的局灶性病变和临床证据相似， 表明基底神经节在工作记忆中起着关键作用。 矛盾的是，工作记忆的成像研究未能 激活基底神经节。 我已经能够展示工作记忆 基底神经节内的激活。 本提案在此基础上提出 以系统的方式提供试点数据。 该项目的目标是 划定基底神经节内对工作重要的区域 记忆并在心理上描述这种激活 构造。 为了实现这一目标，将遵循两个不同的目标。 具体目标 1 下提出的一组实验将利用功能磁共振成像 为了识别基底神经节内的神经基质 特定于工作记忆的不同领域。 如果这样的神经 底物存在，那么这支持了纹状体可能是的论点 以特定于域的方式隔离。 另一个问题是这个 研究旨在解决基底神经节对 工作记忆或工作记忆的中央执行系统 一般（WMG）。 工作记忆的这一方面应用最广泛 认知表现的范围，并与可靠的 推理能力的差异。 fMRI 实验集 具体目标 2 下提出的建议旨在确定 参与中央执行过程的基底神经节。 这 拟议的研究旨在确定涉及的分立元件 基底神经节内的工作记忆可用于 识别由于神经解剖学病变导致的特定功能丧失 发生在临床人群中，例如亨廷顿舞蹈病患者 病、帕金森病、精神分裂症和抽动秽语综合征。