BASAL GANGLIA AND WORKING MEMORY

在动物身上有压倒性的损伤和生理证据 与人类局灶性病变和临床证据相平行 这表明基底节在工作记忆中起着关键作用。 矛盾的是，对工作记忆的成像研究未能 激活基底节。我已经能够展示出工作记忆 基底节内的激活。目前的建议是以此为基础的。 以系统的方式提供试点数据。这个项目的目标是 勾画出基底节内对工作很重要的区域 记忆，并在心理上描述这种激活 建造。实现这一目标将遵循两个不同的目标。 在特定目标1项下提出的一系列实验将利用功能磁共振成像 为了识别基底节内的神经基质， 具体到工作记忆的不同领域。如果这样的神经 底物的存在，这支持了纹状体可能是 以特定于领域的方式进行隔离。另一个问题是，这 这项研究的目的是解决基底神经节对 工作记忆或工作记忆的中央执行系统 一般(WMG)。工作记忆的这一方面被最广泛地使用 认知表现的范围，并已与可靠的 推理能力的差异。一套功能磁共振实验 在具体目标2下提出的建议旨在确定 参与中枢执行过程的基底节。这个 拟议的研究旨在确定涉及到的离散组件 基底节内的工作记忆可用于 确定由于神经解剖损害而导致的特定功能损失 发生在临床人群中，如亨廷顿病患者 疾病、帕金森氏症、精神分裂症和多发性抽动症。

There is overwhelming lesion and physiological evidence in animals paralleled by focal lesions and clinical evidence in humans that suggests that the basal ganglia plays a key role in working memory. Paradoxically, imaging studies of working memory have failed to activate the basal ganglia. I have been able to show working memory activation within the basal ganglia. The present proposal builds on this pilot data in a systematic fashion. The goal of this project is to delineate areas within the basal ganglia that are important for working memory and to characterize this activation within a psychological construct. Two different aims will be followed to achieve this goal. The set of experiments proposed under specific aim 1 will utilize fMRI in order to identify neural substrates within the basal ganglia that are specific to different domains of working memory. If such neural substrates exist, then this supports the thesis that the striatum might be segregated in a domain-specific manner. The other issue that this study is aimed at resolving are the contributions of the basal ganglia to the central executive system of working memory or working memory general (WMG). This aspect of working memory is used in the widest range of cognitive performance and has been linked to reliable differences in reasoning abilities. The set of fMRI experiments proposed under specific aim 2 are aimed at identifying areas within the basal ganglia that are involved in central executive processes. The proposed study aims to identify discrete components involved in working memory within the basal ganglia that can be utilized to identify specific functional loss due to neuroanatomical lesions that occurs in clinical populations, such as in patients with Huntington's disease, Parkinson's disease, Schizophrenia, and Tourette's syndrome.