MODULATION OF AIRWAY EPITHELIAL CELL CYTOKINE PRODUCTION

气道上皮细胞释放多种促炎物质 细胞因子，它们可以通过这些细胞因子调节气道炎症 过程先前的研究已经记录了 促炎细胞因子诱导气道上皮细胞 细胞因子如白细胞介素-6（IL-6）、白细胞介素-8（IL-8）的产生 （IL-8）和粒细胞-巨噬细胞集落刺激因子。气道 神经肽和肽也可以调节气道上皮细胞 应答因此，有必要研究 气道神经肽和其他气道肽对气道细胞因子的影响 生产血管活性肠肽（VIP）是一种神经肽， 去甲肾上腺素能非胆碱能神经系统。VIP添加到 气道上皮细胞系诱导IL-6和IL-8的产生。 类似地，内皮素-1加入到气道上皮细胞系中， 在1和16小时诱导IL-6的产生。知识 上皮细胞产生细胞因子的机制， 调制可以允许更好地理解 炎症性肺病的病理生理学。

Airway epithelial cells release a variety of proinflammatory cytokines by which they may modulate the airway inflammatory process. Prior studies have documented the ability of proinflammatory cytokines to induce airway epithelial cell production of cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte-macrophage colony-stimulating factor. Airway neuropeptides and peptides may also modulate airway epithelial cell responses. Therefore, it was of interest to study the effect of airway neuropeptides and other airway peptides on airway cytokine production. Vasoactive intestinal peptide (VIP) is a neuropeptide of the noradrenergic noncholinergic nervous system. VIP added to an airway epithelial cell line induces production of IL-6 and IL-8. Similarly, endothelin-1 added to an airway epithelial cell line induces production of IL-6 at 1 and 16 hours. Knowledge of the mechanisms by which epithelial cell cytokine production can be modulated may allow for a better understanding of the pathophysiology of inflammatory lung diseases.