MODULATION OF AIRWAY EPITHELIAL CELL CYTOKINE PRODUCTION

气道上皮细胞细胞因子产生的调节

• 批准号: 2571320
• 负责人: J SHELHAMER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2571320
• 关键词: colony stimulating factor; cytokine; endothelin; human tissue; inflammation; interleukin 6; interleukin 8; messenger RNA; neuropeptides; protein biosynthesis; respiratory epithelium; tissue /cell culture; vasoactive intestinal peptide

Airway epithelial cells release a variety of proinflammatory cytokines by which they may modulate the airway inflammatory process. Prior studies have documented the ability of proinflammatory cytokines to induce airway epithelial cell production of cytokines such as interleukin-6 (IL-6), interleukin-8 (IL-8), and granulocyte-macrophage colony-stimulating factor. Airway neuropeptides and peptides may also modulate airway epithelial cell responses. Therefore, it was of interest to study the effect of airway neuropeptides and other airway peptides on airway cytokine production. Vasoactive intestinal peptide (VIP) is a neuropeptide of the noradrenergic noncholinergic nervous system. VIP added to an airway epithelial cell line induces production of IL-6 and IL-8. Similarly, endothelin-1 added to an airway epithelial cell line induces production of IL-6 at 1 and 16 hours. Knowledge of the mechanisms by which epithelial cell cytokine production can be modulated may allow for a better understanding of the pathophysiology of inflammatory lung diseases.

呼吸道上皮细胞释放多种促炎因子 调节呼吸道炎症的细胞因子 进程。先前的研究已经证明了 促炎症细胞因子诱导呼吸道上皮细胞的作用 白介素6、白介素8等细胞因子的产生 (IL-8)和粒细胞-巨噬细胞集落刺激因子。气道口 神经肽和多肽也可能调节呼吸道上皮细胞 回应。因此，研究它的影响是有意义的。 呼吸道神经肽等对呼吸道细胞因子的影响 制作。血管活性肠肽(VIP)是一种神经肽。 去甲肾上腺素能非胆碱能神经系统。VIP已添加到 呼吸道上皮细胞系诱导产生IL-6和IL-8。 同样，将内皮素-1加入到呼吸道上皮细胞系中 在1小时和16小时诱导产生IL-6。了解以下内容 上皮细胞细胞因子产生的机制 调制可以允许更好地理解 炎症性肺病的病理生理学。