SURFACTANT METABOLISM IN AIDS PATIENTS WITH PNEUMOCYSTIS CARINII PNEUMONIA

卡氏肺囊虫肺炎艾滋病患者的表面活性剂代谢

• 批准号: 3853051
• 负责人: J SHELHAMER
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3853051
• 关键词: AIDS; HIV infections; Pneumocystis; Pneumocystis pneumonia; diagnostic respiratory lavage; human subject; hypoxia; lipid metabolism; lysolecithins; opportunistic infections; phospholipase A2; pulmonary surfactants

The mechanisms of hypoxemia and of declining gas exchange in patients with treated and untreated pneumonia due to pneumocystis are not clear. Dr. Hoffman has developed a microtechnique for the measurement of surfactant lipids from Bronchoalveolar Lavage Fluid. To date, 29 samples have been studied. There is evidence of surfactant lipid breakdown with an increase in lysophosphatidyl choline. There is also evidence of increased Phospholipase A2 activity in the Lavage Fluid of these patients. The importance of these studies is that these observations may allow for the development of new or different therapies in this patient population. A manuscript is in preparation.

肺动脉高压患者低氧血症及气体交换功能下降的机制 治疗和未治疗的肺孢子虫肺炎尚不清楚。 博士 霍夫曼发展了一种测量表面活性剂的显微技术 支气管肺泡灌洗液中的脂质。 到目前为止，已经有29个样本 研究了 有证据表明表面活性剂脂质分解， 溶血磷脂酰胆碱 也有证据表明， 这些患者灌洗液中的磷脂酶A2活性。 的 这些研究的重要性在于，这些观察结果可能允许 在该患者人群中开发新的或不同的治疗方法。 一 手稿正在准备中。