SURFACTANT METABOLISM IN AIDS PATIENTS WITH PNEUMOCYSTIS CARINII PNEUMONIA

低氧血症和气体交换减少的机制 因肺孢子虫引起的肺炎治疗和未治疗情况尚不清楚。 霍夫曼博士开发了一种微型技术来测量 从支气管肺泡灌洗液中提取表面活性脂类。到目前为止，29 已经对样品进行了研究。有证据表明表面活性物质的类脂 随着溶血磷脂酰胆碱的增加而分解。还有就是 灌洗液中磷脂酶A2活性升高的证据 这些病人。这些研究的重要性在于，这些 观察可能允许开发新的或不同的治疗方法 在这群病人中。一份手稿正在准备中。本研究 已经扩展到评估皮质类固醇的效果 HIV感染者BAL中表面活性物质血脂水平的给药 肺孢子虫肺炎患者。

The mechanisms of hypoxemia and of declining gas exchange in patients with treated and untreated pneumonia due to pneumocystis is not clear. Dr Hoffman has developed a microtechnique for the measurement of surfactant lipids from Bronchoalveolar Lavage Fluid. To date, 29 samples have been studied. There is evidence of surfactant lipid breakdown with an increase in lysophosphatidyl choline. There is also evidence of increased Phospholipase A2 activity in the lavage Fluid of these patients. The importance of these studies is that these observations may allow for the development of new or different therapies in this patient population. A manuscript is in preparation. This study has been extended to evaluate the effect of corticosteroid administration on surfactant lipid levels in the BAL of HIV infected patients with Pneumocystis pneumonia.