SURFACTANT METABOLISM IN AIDS PATIENTS WITH PNEUMOCYSTIS CARINII PNEUMONIA

患者低氧血症和气体交换下降的机制 治疗和未治疗的肺孢子虫肺炎是不清楚的。 霍夫曼博士发明了一种显微技术 支气管肺泡灌洗液中的表面活性剂脂质。 迄今为止， 样品进行了研究。 有证据表明表面活性剂脂质 溶血磷脂酰胆碱增加而分解。 还有 在灌洗液中磷脂酶A2活性增加的证据 这些病人。 这些研究的重要性在于， 观察结果可能有助于开发新的或不同的治疗方法 in this patient患者population人口. 手稿正在准备中。 本研究 已扩展到评价皮质类固醇的作用 给药对HIV感染者BAL中表面活性物质脂质水平的影响 肺孢子虫肺炎患者。

The mechanisms of hypoxemia and of declining gas exchange in patients with treated and untreated pneumonia due to pneumocystis is not clear. Dr Hoffman has developed a microtechnique for the measurement of surfactant lipids from Bronchoalveolar Lavage Fluid. To date, 29 samples have been studied. There is evidence of surfactant lipid breakdown with an increase in lysophosphatidyl choline. There is also evidence of increased Phospholipase A2 activity in the lavage Fluid of these patients. The importance of these studies is that these observations may allow for the development of new or different therapies in this patient population. A manuscript is in preparation. This study has been extended to evaluate the effect of corticosteroid administration on surfactant lipid levels in the BAL of HIV infected patients with Pneumocystis pneumonia.