MODULATION OF AIRWAY EPITHELIAL CELL CYTOKINE PRODUCTION

气道上皮细胞释放多种促炎细胞因子， 它们可以调节气道炎症过程。先前研究 已经证明了促炎细胞因子诱导气道炎症的能力， 上皮细胞产生细胞因子如白细胞介素-6（IL-6）， 白细胞介素-8（IL-8）和GM-CSF。气道神经肽和肽也可以 调节气道上皮细胞反应。因此， 研究气道神经肽和其他气道肽对 气道细胞因子产生。血管活性肠肽（VIP）是一种 非肾上腺素能非胆碱能神经系统的神经肽。VIP添加 诱导IL-6和IL-8的产生。 类似地，将内皮素-1添加到气道上皮细胞系中诱导 产生IL-6和IL-8。上皮细胞稳态变化的研究 说明IL-6和IL-8对VIP和内皮素-1应答的mRNA水平， 以及气道中局部产生的其它介质。 了解上皮细胞产生细胞因子的机制 可以被调制可以允许更好地理解 炎症性肺病的病理生理学。

Airway epithelial cells release a variety of proinflammatory cytokines by which they may modulate the airway inflammatory process. Prior studies have documented the ability of proinflammatory cytokines to induce airway epithelial cell production of cytokines such as Interleukin-6(IL-6), Interleukin-8(IL-8) and GM-CSF. Airway neuropeptides and peptides may also modulate airway epithelial cell responses. Therefore, it was of interest to study the effect of airway neuropeptides and other airway peptides on airway cytokine production. Vasoactive intestinal peptide(VIP) is a neuropeptide of the nonadrenergic noncholinergic nervous system. VIP added to an airway epithelial cell line induces production of IL-6 and IL-8. Similarly, Endothelin-1 added to an airway epithelial cell line induces production of IL-6 and IL-8. Studies of changes in epithelial cell steady state mRNA levels for IL-6 and IL-8 in response to VIP and Endothelin-1 as well as other mediators locally produced in the airway are in progress. Knowledge of the mechanisms by which epithelial cell cytokine production may be modulated may allow for a better understanding of the pathophysiology of inflammatory lung diseases.