FIELD TRIAL OF KILLED ORAL CHOLERA VACCINES IN VIETNAM

在越南，霍乱仍然是一个严重的公共卫生问题。在.期间 20世纪80年代末，美国国家卫生和流行病学研究所 越南仿照瑞典人研制出一种口服霍乱灭活疫苗 孟加拉分支机构调查人员在 20世纪80年代中期。这种疫苗在顺化的现场试验，招募了10万人 受试者发现，疫苗对El Tor的保护率约为60% 霍乱，对幼儿和老年人有类似的疗效。 这种早期的疫苗现在已经扩大到包括预防 新发现的0139群霍乱弧菌。这是一次预试 该疫苗的安全性和免疫原性最近在美国进行。 河内的成年人。在接下来的9个月里，类似的预试将是 在河内儿童中进行，并进行了大规模的疫苗现场试验 将于明年3月在沿海城市芽庄启动。这 试验将招募约20万人，并将评估临床 在接种疫苗后两年内疫苗的有效性。

Cholera remains a significant public health problem in Vietnam. During the late 1980s, the National Institute of Hygiene and Epidemiology of Vietnam developed a killed oral cholera vaccine modelled on a Swedish vaccine tested by Branch investigators in Bangladesh during the mid-1980s. A field trial of this vaccine in Hue, which enrolled 100,000 subjects, found the vaccine to confer about 60% protection against El Tor cholera, with similar efficacy in young children and in older persons. This earlier vaccine has now been augmented to include coverage against the newly recognized 0139 serogroup of V. cholerae. A pretest of the safety and immunogenicity of this vaccine was recently conducted in adults in Hanoi. During the next 9 months, a similar pretest will be conducted in Hanoi children, and a large-scale field trial of the vaccine will be initiated in the coastal city of Nha Trang next March. This trial will enroll about 200,000 persons, and will assess the clinical effectiveness of the vaccine over two years following vaccination.