FRONTAL LOBE AND CEREBRAL CONTROL OF ADAPTIVE SPATIAL-MOTOR BEHAVIOR
自适应空间运动行为的额叶和大脑控制
基本信息
- 批准号:2578697
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
This project studies neural mechanisms underlying processing of cognitive
information and the learning of motor adaptations associated with
spatial-motor behavior. Single unit activity is measured in monkeys
trained to perform multidirectional reaching movements during instructed-
delay tasks. The frontal lobe is an important structure for the
generation of (a) reaching behavior in extrapersonal space, (b) proper
movement sequencing, and (c) the utilization of requisite information
from memory and sensory systems for guided movements. This is a
behavioral neurophysiology study of three major divisions of the frontal
lobe of primates: the primary motor cortex (M1), dorsal premotor cortex
(Pmd), and supplementary motor area (SMA). Two paradigms involving the
serial presentation of spatial information are used to investigate each
cortical area and the processing of requisite visual-spatial information
for reaching. In one a previously learned movement sequence is prepared
and executed by a monkey. This task will determine which specific
attributes of spatial reaching are encoded at the cortical level and
whether movement sequences are represented in neural signals as
transformation between spatial representations off component movement
segments, or, as representations of the relationship between the first
and second movement segments. In the second task, a robot arm is used
to rapidly change the mechanical environment of reaching movements and
accordingly modify the sensorimotor experience of producing different
reaching movements with the same starting and final arm positions. The
robot arm will rapidly produce unfamiliar mechanical environments and
simulate collisions between the arm and "virtual" objects at specific
locations along the movement trajectory. This design will allow the
neural correlates of learned adaption of spatial-motor behavior to be
studied.
本项目研究认知加工的神经机制
信息和学习运动适应相关的
空间运动行为 单个单位活动是在猴子身上测量的
训练在指导期间进行多方向的伸展运动-
延迟任务。 额叶是大脑的重要结构,
产生(a)在个人以外的空间中达到行为,(B)适当的
(c)必要信息的利用
从记忆和感觉系统来引导运动。 这是一
额叶三个主要分区的行为神经生理学研究
灵长类的叶:初级运动皮层(M1),背侧运动前皮层
(Pmd)补充运动区(SMA)。 两个范例涉及
空间信息的连续呈现被用来调查每个
皮质区和必要的视觉空间信息的处理
为了达到。 在一个先前学习的运动序列准备
然后被猴子处决 这项任务将确定哪些具体的
空间到达的属性在皮层水平编码,
运动序列在神经信号中是否表现为
构件运动空间表示之间的转换
段,或者,作为第一段之间关系的表示,
和第二运动段。 在第二个任务中,使用了机器人手臂
以快速改变伸展运动的机械环境,
相应地修改产生不同的感觉运动体验,
以相同的起始和最终手臂位置进行伸展运动。 的
机器人手臂将迅速产生不熟悉的机械环境,
模拟手臂和“虚拟”物体之间的碰撞,
沿移动轨迹的沿着位置。 该设计将允许
空间运动行为的学习适应的神经相关性
研究了
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donald J. Crammond其他文献
Refining centromedian nucleus stimulation for generalized epilepsy with targeting and mechanistic insights from intraoperative electrophysiology
基于术中电生理学的靶点定位及机制研究对广泛性癫痫的扣带回中央核刺激的改进
- DOI:
10.1038/s41467-025-60183-9 - 发表时间:
2025-06-06 - 期刊:
- 影响因子:15.700
- 作者:
Jonathan C. Ho;Thandar Aung;Arianna Damiani;Lilly Tang;Arka N. Mallela;Donald J. Crammond;Jorge A. González-Martínez - 通讯作者:
Jorge A. González-Martínez
Optimal “Low” Pedicle Screw Stimulation Threshold to Predict New Postoperative Lower-Extremity Neurologic Deficits During Lumbar Spinal Fusions
- DOI:
10.1016/j.wneu.2021.04.022 - 发表时间:
2021-07-01 - 期刊:
- 影响因子:
- 作者:
Samyuktha R. Melachuri;Manasa K. Melachuri;Amir Mina;Katherine Anetakis;Donald J. Crammond;Jeffrey R. Balzer;Varun Shandal;Parthasarathy D. Thirumala - 通讯作者:
Parthasarathy D. Thirumala
Role of Intraoperative Neurophysiologic Monitoring in Internal Carotid Artery Injury During Endoscopic Endonasal Skull Base Surgery
- DOI:
10.1016/j.wneu.2020.11.154 - 发表时间:
2021-04-01 - 期刊:
- 影响因子:
- 作者:
Yasodara Priyadharsini Senthamarai Siddharthan;Ammar Bata;Katherine Anetakis;Donald J. Crammond;Jeffrey R. Balzer;Carl Snyderman;Paul Gardner;Parthasarathy D. Thirumala - 通讯作者:
Parthasarathy D. Thirumala
Intraoperative neuromonitoring as real-time diagnostic for cerebral ischemia in endovascular treatment of ruptured brain aneurysms
- DOI:
10.1016/j.clinph.2024.02.024 - 发表时间:
2024-05-01 - 期刊:
- 影响因子:
- 作者:
Abdullah M. Al-Qudah;Parthasarathy D. Thirumala;Katherine M. Anetakis;Donald J. Crammond;Saleh A. Algarni;Mohammad AlMajali;Varun Shandal;Bradley A. Gross;Michael Lang;Nirav R. Bhatt;Alhamza R. Al-Bayati;Raul G. Nogueira;Jeffrey R. Balzer - 通讯作者:
Jeffrey R. Balzer
The diagnostic accuracy of somatosensory evoked potentials in evaluating neurological deficits during 1057 lumbar interbody fusions
- DOI:
10.1016/j.jocn.2018.10.140 - 发表时间:
2019-03-01 - 期刊:
- 影响因子:
- 作者:
Samyuktha R. Melachuri;Jaspreet Kaur;Manasa K. Melachuri;David Ninaci;Donald J. Crammond;Jeffrey R. Balzer;Parthasarathy D. Thirumala - 通讯作者:
Parthasarathy D. Thirumala
Donald J. Crammond的其他文献
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{{ truncateString('Donald J. Crammond', 18)}}的其他基金
FRONTAL LOBE AND CEREBRAL CONTROL OF ADAPTIVE SPATIAL/MOTOR BEHAVIOR
自适应空间/运动行为的额叶和大脑控制
- 批准号:
6162851 - 财政年份:
- 资助金额:
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