FRONTAL LOBE AND CEREBRAL CONTROL OF ADAPTIVE SPATIAL-MOTOR BEHAVIOR

本课题研究认知加工的神经机制。 与运动适应相关的信息和学习 空间运动行为。单个单位的活动是以猴子为单位进行测量的 受过训练，在接受指导的过程中进行多方向伸展动作 延迟任务。额叶是大脑的一个重要结构。 产生(A)在个人以外的空间中达到行为，(B)适当 移动排序，以及(C)必要信息的利用 来自记忆和感觉系统的引导运动。这是一个 额叶三大区的行为神经生理学研究 灵长类脑叶：初级运动皮质(M1)、背侧前运动皮质 (PMD)和辅助运动区(SMA)。两个范例涉及 空间信息的连续表示被用来调查每个 大脑皮层区域与必要视觉空间信息的处理 为了伸手可及。在一种情况下，准备先前学习的运动序列 被一只猴子处死。此任务将确定哪个特定的 空间到达的属性在大脑皮层水平上编码，并且 运动序列是否在神经信号中表示为 组件移动后的空间表示之间的转换 段，或者，作为第一个 和第二运动段。在第二个任务中，使用了机器人手臂 迅速改变伸展运动的机械环境 相应地修改产生不同的感觉运动体验 以相同的起始和最后手臂位置达到动作。这个 机械臂将迅速产生不熟悉的机械环境和 在特定位置模拟手臂和虚拟对象之间的碰撞 沿运动轨迹的位置。这一设计将允许 空间运动行为习得性适应的神经相关性研究 学习。

This project studies neural mechanisms underlying processing of cognitive information and the learning of motor adaptations associated with spatial-motor behavior. Single unit activity is measured in monkeys trained to perform multidirectional reaching movements during instructed- delay tasks. The frontal lobe is an important structure for the generation of (a) reaching behavior in extrapersonal space, (b) proper movement sequencing, and (c) the utilization of requisite information from memory and sensory systems for guided movements. This is a behavioral neurophysiology study of three major divisions of the frontal lobe of primates: the primary motor cortex (M1), dorsal premotor cortex (Pmd), and supplementary motor area (SMA). Two paradigms involving the serial presentation of spatial information are used to investigate each cortical area and the processing of requisite visual-spatial information for reaching. In one a previously learned movement sequence is prepared and executed by a monkey. This task will determine which specific attributes of spatial reaching are encoded at the cortical level and whether movement sequences are represented in neural signals as transformation between spatial representations off component movement segments, or, as representations of the relationship between the first and second movement segments. In the second task, a robot arm is used to rapidly change the mechanical environment of reaching movements and accordingly modify the sensorimotor experience of producing different reaching movements with the same starting and final arm positions. The robot arm will rapidly produce unfamiliar mechanical environments and simulate collisions between the arm and "virtual" objects at specific locations along the movement trajectory. This design will allow the neural correlates of learned adaption of spatial-motor behavior to be studied.