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DRUG TRANSPORT IN BRAIN

DRUG TRANSPORT IN BRAIN
大脑中的药物转运
批准号:
2590318
负责人:
P F MORRISON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
这个项目是关于描述和改进交付的
英文摘要
This project is concerned with characterizing and improving the delivery of pharmacologic and diagnostic agents to the brain. A previously developed theory of microinfusion based on flow in porous media, microvascular transport, and brain metabolism was used to predict large penetration and relatively even dosing of tissue for high-flow microinfusion of macromolecules. We confirmed multi-centimeter macromolecular penetration of white matter in the cat brain via autoradiography, as well as flat concentration profiles and expected spread in the gray matter of rats. We performed a SPECT study in primates and phantoms, thus demonstrating this technique's ability to monitor delivery and characterize tissue spread, clearance, and effects on blood flow. Model computations were invoked to screen the ability of available contrast agents (iopamidol and Gd-DTPA-albumin) to track macromolecular agents in normal and tumorous brain. Based on porous media flow and deformation theory, a mathematical model of backflow of infusate along catheter shafts was developed as a function of flow rate, catheter diameter, and tissue parameters. This included the development of a new nondimensional scalar that is useful for selecting optimal catheter diameter and flow-rate combinations. To ascertain optimal infusion parameters for excitotoxin pallidotomy of Parkinson's disease, we also developed a mathematical model of quinolinic acid infusion into small gray matter nuclei.
期刊论文(0)
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会议论文
THYMIDYLATE SYNTHASE REGULATION
KINETICS OF FOLATE METABOLISM
THYMIDYLATE SYNTHASE REGULATION
SULFONE STRUCTURE-ACTIVITY ANALYSIS
  • 批准号:
    3916238
  • 项目类别:
  • 资助金额:
    $0.0万
  • 财政年份:
    --
  • 负责人:
    P F MORRISON
  • 依托单位:
海外基金