AGING BRAIN--VASCULATURE, ISCHEMIA AND BEHAVIOR

大脑老化——血管、缺血和行为

• 批准号: 2516991
• 负责人: HELENA Chang CHUI
• 金额: $ 139.64万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-09-30 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2516991
• 关键词: cerebral ischemia /hypoxia; cerebrovascular disorders

The main objective of this program project is to determine how structural changes in the cerebral vasculature affect brain function and behavior in elderly persons. The knowledge and understanding obtained from this project is intended to provide a solid base for developing effective treatment for highly prevalent and clinically significant disorders. Various changes in the cerebral vasculature (atherosclerosis, arteriosclerosis, amyloid angiopathy) will be systematically quantified in Project 4. The pathophysiology of chronic ischemia, which may play a particularly important role in persons with slowly progressive cognitive decline, will be examined in project 3. The metabolic, physiologic, and behavioral correlates of lacunar infarction and deep white matter changes will be investigated in projects 1, 2, and 3. Finally, questions related to natural history, clinico-pathologic correlation and diagnosis are addressed jointly by three Cores. The relationship between vasculature, ischemia, and behavior is complex; understanding requires a comprehensive inter-disciplinary approach. The program project represents a multi-institutional collaborative effort involving investigators at the University of Southern California and the University of California at Irvine, Los Angeles, San Francisco and Davis. Clinical recruitment and longitudinal follow-up will take place at 6 Alzheimer Disease Diagnostic and Treatment Centers (ADDTC) supported by the State of California. Whenever possible, provisions have been made to share resources (such as patients, protocols, data, and tissues) across the program. From both a thematic and logistical standpoints, we have attempted to create a highly-cohesive and cost-effective research program.

该项目的主要目标是确定结构如何 脑血管系统的变化会影响脑功能和行为 在老年人中。 由此获得的知识和理解 该项目旨在为制定有效的 治疗高度流行和临床显著的疾病。 脑血管系统的各种变化（动脉粥样硬化， 动脉硬化、淀粉样血管病）将被系统地量化 在项目4中。 慢性缺血的病理生理学，这可能发挥 在缓慢进展的人中， 认知能力下降，将在项目3中进行研究。 新陈代谢， 生理和行为相关的腔隙性脑梗死和深 将在项目1、2和3中研究白色物质变化。 最后，与自然史、临床病理学 相关性和诊断由三个核心共同解决。 血管、缺血和行为之间的关系是复杂的; 理解需要一种全面的跨学科方法。 的 一个计划项目代表了一个多机构的合作努力 涉及南加州大学和 加州大学欧文分校、洛杉矶分校、旧金山弗朗西斯科分校和戴维斯分校。 临床招募和纵向随访将在6时进行 阿尔茨海默病诊断和治疗中心（ADDTC）由 加州州。 在可能的情况下， 共享资源（如患者、方案、数据和组织） 在整个程序中。 从主题和后勤的角度来看，我们 试图建立一个高度凝聚力和成本效益的研究 程序.