CYTOKINE/VIRAL GENE INTERACTIONS IN VIRAL LUNG DISEASE

人类巨细胞病毒和腺病毒都是 与严重的肺部疾病相关，既有活动期也有潜伏期 感染。与这些病原体潜伏感染相关的疾病 可包括闭塞性毛细支气管炎、支气管扩张症、高透视症 肺综合征和其他形式的慢性阻塞性肺疾病，以及 同种异体肺移植后移植物抗宿主病的加速 移植。这些情况的发生可能是由于 致炎细胞因子的病理性产生 病毒基因产物与细胞因子基因之间的相互作用。 这项研究计划试图了解这些机制 与最终改善治疗和治疗的目标的互动 预防与潜伏病毒感染相关的疾病。

Both human cytomegalovirus and adenovirus are viruses which are associated with severe lung disease in active as well as latent infection. Disorders associated with latent infection by these pathogens may include bronchiolitis obliterans, bronchiectasis, the hyperlucent lung syndrome and other forms of chronic obstructive lung disease, and acceleration of graft versus host disease following allogeneic lung transplantation. Development of these conditions may result from the pathologic production of pro-inflammatory cytokines resulting from interactions between the viral gene products and the cytokine genes. This research proposal seeks to understand the mechanisms of these interactions with the goal of eventually improving treatment and prevention of disorders associated with latent viral infection.