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FUNCTIONAL NEUROIMAGING OF SENSORY-MOTOR INTEGRATION

感觉运动整合的功能神经影像

基本信息

批准号：
2519863
负责人：
ROGER P WOODS
金额：
$ 7.48万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
起止时间：
1993-09-01 至 1999-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2519863
关键词：
autoradiography brain circulation brain disorder diagnosis brain mapping cerebral dominance electrophysiology handedness human subject magnetic resonance imaging mathematical model method development model design /development neurophysiology parietal lobe /cortex positron emission tomography radiotracer sensorimotor system

项目摘要

The objectives of this proposal are: i) to optimize and validate positron emission tomography (PET) activation techniques as a method of functional brain mapping in single subjects, and 2) to apply these techniques to better understand processes of sensory-motor integration in the human. PET studies will use radioactively labeled water as a means of measuring regional changes in blood flow in response to behavioral tasks. The methodologic aspects of this proposal will focus on improvements in signal-to-noise ratios by using better imaging protocols, development of more accurate statistical models for analyzing data from individual subjects, and independent validation of PET findings by comparing the results with those obtained using other methods of functional evaluation. The objective of these methodologic investigations is to develop functional brain imaging as a valid, rigorous tool for the study of normal and abnormal brain physiology in individual subjects. The objective of the neuroscientific component of the proposal is to use this tool to better understand sensory-motor integration in the human. Initial studies will map sensory-motor processes in normal subjects as a function of the sensory input modality and the motor output modality. Participation of the parietal lobe in sensory-motor tasks will be of particular interest, but the demonstration of one or more widespread cortical networks involved in sensory-motor integration is anticipated. Further studies will examine the -lateralization of sensory-motor processing in normal subjects to look for evidence of hemispheric asymmetries. During the final two years of the proposal, patients with sensory-motor deficits and/or with lesions in brain structures normally involved in sensory-motor integration will be studied. Multimodal integration of clinical observations, functional imaging studies, anatomic imaging studies, and electrophysiologic measurements will be utilized in normal subjects and in patients to further clarify the relationship between brain structure and function.

该提案的目标是：i）优化和验证正电子发射断层扫描（PET）激活技术作为一种方法的功能在单个受试者中绘制大脑地图，2）将这些技术应用于更好地理解人类的感觉运动整合过程。 PET研究将使用放射性标记的水作为测量手段，对行为任务作出反应的血流区域变化。的本建议的方法方面将侧重于改进通过使用更好的成像协议，更准确的统计模型，用于分析个人数据受试者，并通过比较结果与使用其他功能评估方法获得的结果一致。这些方法学研究的目的是发展脑功能成像作为一种有效的，严格的工具，研究正常的和异常的大脑生理学。该提案的神经科学部分的目标是使用这个工具可以更好地理解人类的感觉-运动整合。初步研究将绘制正常受试者的感觉运动过程，作为感觉输入模态和运动输出模态的功能。顶叶在感觉运动任务中的参与将是特别感兴趣，但一个或多个广泛的示范参与感觉-运动整合的皮层网络是预期的。进一步的研究将检查感觉运动的偏侧化在正常受试者中寻找大脑半球不对称。在提案的最后两年，感觉-运动缺陷和/或脑结构损伤，将研究与感觉运动整合有关的问题。多式整合临床观察、功能成像研究、解剖学影像学研究和电生理测量将用于进一步明确正常人与患者的关系大脑结构和功能之间的联系