VISUAL/SPATIAL PROPERTIES OF AREA 7 NEURONS

区域 7 神经元的视觉/空间特性

• 批准号: 2608579
• 负责人: RICHARD A ANDERSEN
• 金额: $ 33.19万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2608579
• 关键词: Macaca mulatta; bacterial polysaccharides; behavior test; behavioral /social science research tag; brain electrical activity; brain mapping; eye movements; head movements; histology; neural information processing; neuroanatomy; neurons; neurophysiology; parietal lobe /cortex; single cell analysis; space perception; vision tests; visual pathways; visual stimulus

DESCRIPTION: Lesions of the posterior parietal cortex (PPC) in humans and monkeys produce deficits in visual attention, spatial perception, and the ability to make accurate movements. These deficits are the result of losing the cortical pathway which enables visual information to be transformed into action. This proposal will examine how this transformation is accomplished by recording the activity of neurons in the PPC of monkeys while they perform various visual-motor tasks. The proposal will focus on whether a component in PPC is already coding movement intentions, whether these intentions are coded in the motor coordinates of the movement being planned, and how the different sensory signals that converge on PPC are transformed into various spatial coordinate frames. The role of gain fields (the modulations of sensory signals by eye, head and limb position) in transforming between coordinate frames will be examined. The first specific aim will examine movement intention and will determine if cells in area LIP are specifically engaged in saccade tasks, and if cortical areas around LIP are specifically engaged in reach tasks. The second specific aim will determine if reach-related areas are coding visually derived signals in limb coordinates. Such a finding would indicate that visual signals have been transformed into motor coordinates for the purpose of moving the limbs. The third specific aim will examine how head position signals are combined with eye position and visual (retinal position) signals to code the spatial locations of objects. It will be determined if vestibular signals, which convey information about the location of the head in the world, affect the visual response of PPC neurons; these vestibular gain fields could potentially encode locations in world-centered coordinates. Likewise it will be determined if neck proprioceptive or efference copy signals, conveying the orientation of the head on the body, modulate visual responsiveness and potentially encode locations in body-centered coordinates. Finally the role of optical flow and visual landmark cues in coding the locations of visual stimuli in world-centered coordinates will be examined. The fourth specific aim will be to determine how visual and auditory signals are combined in PPC to code spatial locations independent of the modality of the stimulus. These experiments, particularly the third and fourth aims, are designed to answer the long standing question of how different modalities are combined into a common framework in parietal association cortex. Overall these experiments will significantly further our understanding of how perceptions are transformed into actions.

描述：人类后顶叶皮层（PPC）的病变， 猴子的视觉注意力、空间知觉和 能够准确的移动。 这些赤字是由于失去 大脑皮层通路使视觉信息能够转化为 行动上 本提案将研究如何实现这一转变 通过记录猴子PPC中神经元的活动， 执行各种视觉运动任务。 该提案将重点关注 PPC中的组件已经在编码运动意图，无论这些 意图被编码在所计划的运动的运动坐标中， 以及不同的感觉信号如何在PPC上转换 不同的空间坐标系。 增益场的作用（ 通过眼睛、头部和肢体位置对感觉信号的调制）， 将检查坐标框架之间的变换。 第一特定 aim将检查运动意图，并将确定LIP区域中的细胞是否 是专门从事扫视任务，如果LIP周围的皮层区域 专门从事接触任务。 第二个具体目标将 确定伸手相关区域是否正在对肢体中的视觉衍生信号进行编码 坐标 这一发现表明，视觉信号已经被 转换成运动坐标以移动肢体。 的 第三个具体目标将研究头部位置信号如何与 眼睛位置和视觉（视网膜位置）信号来编码空间 物体的位置。 将确定是否前庭信号， 传达关于头部在世界上的位置的信息，影响 PPC神经元的视觉反应;这些前庭增益场可以 潜在地以世界为中心的坐标编码位置。 同样， 将确定颈部本体感受或传出复制信号， 传达头部在身体上的方位，调节视觉 响应性和潜在的编码位置， 坐标 最后，光流和视觉地标线索的作用， 在以世界为中心的坐标中编码视觉刺激的位置将是 考察 第四个具体目标将是确定如何视觉和 在PPC中组合听觉信号以独立于空间位置编码 刺激的形式。 这些实验，特别是第三次 和第四个目标，旨在回答长期存在的问题， 不同的模态被组合成一个共同的框架， 联合皮层 总的来说，这些实验将大大促进 我们对感知如何转化为行动的理解。