ACTIVE MIXING MEMBRANE OXYGENATOR (AMMO)

PADI肺科技术有限公司(CPT)及其发展伙伴， 匹兹堡大学（UOP）设计了一个原型， 膜式氧合器（AMMO），我们认为它在 氧合/脱碳方面优于目前临床使用的产品。 AMMO概念通过以下方式实现有效的血液氧合： 旋转/反向旋转流通盘，由微孔材料制成 中空纤维膜，其安装在双腔轴上。 在 已经获得了体外和体内可行性数据，其中我们 成功地证明了我们AMMO概念提供了高效的 血液氧合/脱碳，溶血最小。 我们提出的 第一阶段的计划是通过进一步改善 AMMO设计;研究其他旋转/反向旋转策略， AMMO圆盘;评估体外O2/CO2交换效率， 每个AMMO原型的溶血潜力;演示AMMO系统 最佳盘旋转/反转策略的可靠性 选择;和，评估含氟聚合物涂料的可能用途 弹药的事使用小牛的两项体内试验将用于证明 高效的血液氧合，基本的生物相容性， AMMO在儿童和成人条件下的溶血潜力 血流动力学状况。 拟议的商业应用： 本研究作为心肺产品具有商业应用价值 销售给美国和国外的医院。AMMO设备将是低 成本一次性单位或使用。每家医院都可能维持 几个在他们的库存。

CardioPulmonary Technologies, Inc. (CPT) and its development partner, the University of Pittsburgh (UOP) have designed a prototype, active mixing membrane oxygenator (AMMO) which we believe is much more efficient in terms of oxygenation/decarbonation than current clinical use products. The AMMO concept achieves efficient blood oxygenation by rotating/counter-rotating flow-through disks, constructed of microporous hollow fiber membranes, which are mounted on a double lumen shaft. In vitro and in vivo feasibility data has been obtained in which we successfully demonstrate that our AMMO concept provides highly efficient blood oxygenation/decarbonation with minimal hemolysis. Our proposed Phase I plan is to extend this feasibility work by further improving the AMMO design; investigating other rotating/counter-rotating strategies for the AMMO discs; assessing in vitro O2/CO2 exchange efficiency and hemolysis potential for each AMMO prototype; demonstrating AMMO system reliability at the optimum disc rotation/counter rotation strategy selected; and, evaluating fluoropolymer coatings for their possible use with the AMMO. Two in vivo tests using calves will serve to demonstrate highly efficient blood oxygenation, basic biocompatibility, and low hemolysis potential of the AMMO under both pediatric and adult hemodynamic conditions. PROPOSED COMMERCIAL APPLICATIONS: This research has commercial application as a cardiopulmonary product marketed to hospitals in the U.S. and abroad. AMMO devices will be low cost disposable units for OR use. Each hospital would probably maintain several in their inventory.