High Efficiency Dialyzer Development

本项目的目标是开发一种高效的主动式搅拌器 一种用于肾衰竭患者血液透析器。我们打算复制 主动混合膜式氧合器（AMMO）技术目前 正在开发中的设备。AMMO装置中的质量传递 被证明是5-8倍的效率比目前可用的静态 氧合器，虽然不会造成比这些临床 装置.此外，AMMO的旋转运动导致 它是一个非常有效的泵，从而结合了两个基本的 功能在一个单一的设备。 主动混合的功能是通过赋予间隙混合物 中空纤维阵列内的对流和减少血液相 阻力，从而提高传质效率。换句 换言之，纤维束的运动破坏了浓度边界 层，其阻碍跨膜的质量传递。 该第一阶段计划旨在评估我们的 设计具体地说，使用为 AMMO我们将制造多个主动混合透析器原型 适当透析微孔纤维和透析液的变化 液体通道然后将根据AAMI对这些装置进行体外评价 标准根据获得的清除数据，我们将选择 高效的透析器，并制造一套相同的单元， 功能评价最后，三个离体动物试验，以评估基本的 主动混合透析器的生物相容性。 拟定商业应用： 超过20万美国人需要血液透析。活性 混合血液透析器具有提供更有效， 因此耗时更少和生物材料暴露更少， 血液透析治疗。此外，这个装置还能将血液 从而消除了当前系统的另一个元件。将 可集成到当今的透析机中， 昂贵的资本支出。

The goal of this project is develop a highly efficient active mixing hemodialyzer for patients in renal failure. We intend to replicate our active mixing membrane oxygenator (AMMO) technology currently under development to this device. Mass transfer in AMMO devices has proven to be 5-8 times more efficient than currently available static oxygenators, while not causing more blood damage than these clinical devices. In addition, the rotational movement of AMMO has resulted in it being a very efficient pump, thereby incorporating two basic functions in a single device. Active mixing functions to increase efficiency by imparting interstitial convection within the hollow fiber array and reducing blood phase resistance, resulting in increased mass transfer efficiency. In other words, motion of the fiber bundle disrupts the concentration boundry layer that impedes mass transfer across the membrane. This Phase I program is designed to evaluate the feasibility of our design. Specifically, using fabrication techniques developed for AMMO we will fabricate multiple active mixing dialyzer prototype variations with appropriate dialysis microporous fibers and dialysate fluid pathways. These units will then be evaluated in vitro per AAMI standards. Based on clearance data obtained we will select the most efficient dialyzer and fabricate a set of identical units for further functional evaluation. Finally, three ex-vivo animal trials to assess basic biocompatibility of the active mixing dialyzer are proposed. PROPOSED COMMERCIAL APPLICATION: Hemodialysis is required by over 200,000 Americans. The active mixing hemodialyzer has the potential to provide for more efficient, hence less time-consuming and lower biomaterials exposure, hemodialysis treatments. In addition, this device will pump blood thereby eliminating another element of current systems. It will be integratable into today's dialysis machines thereby eliminating the need for costly capital expenditures.