THROMBORESISTANT POLYURETHANE CARDIAC VALVE DEVELOPMENT
抗血栓聚氨酯心脏瓣膜的开发
基本信息
- 批准号:3501211
- 负责人:
- 金额:$ 4.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-01-10 至 1988-12-13
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
A new cardiac valve fabricated from a novel polyurethane
material has been fabricated and tested in vitro. These
preliminary tests indicate that this device is durable (no failures
in tests lasting at least 200 million cycles) and possesses
hemodynamic characteristics comparable to currently available
valves.
The segmented polyurethaneurea developed for this use is unique
because its bulk properties, for long-term durability, and surface
properties, for biocompatibility, have been separated and
developed in two distinct materials. Blending of the two
components results in a single material incorporating the
properties of each. In vivo evaluation of rods of this material and
of ventricular assist device pumping sacs has demonstrated its
excellent physical and thromboresistant characteristics.
We propose to fabricate valves and test them both in vitro and in
vivo. Steady-state and pulsatile conditions will be used for the
mock loop testing. Valves will be implanted in left ventricle to
aorta shunts in calves, a model that we have used many times to
evaluate other devices. Additional hemodynamic testing will be
performed on explanted valves, as will SEM and X-ray analysis.
用新型聚氨酯制成的新型心脏瓣膜
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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PHILIP LITWAK其他文献
PHILIP LITWAK的其他文献
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{{ truncateString('PHILIP LITWAK', 18)}}的其他基金
Simplified Pump Oxygenator for Pediatric Use Phase II
儿科简易泵氧合器第二期
- 批准号:
6550618 - 财政年份:2001
- 资助金额:
$ 4.99万 - 项目类别:
DEVELOPMENT OF A COMPLIANT HEMODIALYSIS ACCESS GRAFT
开发顺应性血液透析通路移植物
- 批准号:
3638535 - 财政年份:1989
- 资助金额:
$ 4.99万 - 项目类别:
DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT
高度顺应性血管移植物的开发
- 批准号:
3508462 - 财政年份:1987
- 资助金额:
$ 4.99万 - 项目类别: