THROMBORESISTANT POLYURETHANE CARDIAC VALVE DEVELOPMENT

抗血栓聚氨酯心脏瓣膜的开发

基本信息

  • 批准号:
    3501211
  • 负责人:
  • 金额:
    $ 4.99万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-01-10 至 1988-12-13
  • 项目状态:
    已结题

项目摘要

A new cardiac valve fabricated from a novel polyurethane material has been fabricated and tested in vitro. These preliminary tests indicate that this device is durable (no failures in tests lasting at least 200 million cycles) and possesses hemodynamic characteristics comparable to currently available valves. The segmented polyurethaneurea developed for this use is unique because its bulk properties, for long-term durability, and surface properties, for biocompatibility, have been separated and developed in two distinct materials. Blending of the two components results in a single material incorporating the properties of each. In vivo evaluation of rods of this material and of ventricular assist device pumping sacs has demonstrated its excellent physical and thromboresistant characteristics. We propose to fabricate valves and test them both in vitro and in vivo. Steady-state and pulsatile conditions will be used for the mock loop testing. Valves will be implanted in left ventricle to aorta shunts in calves, a model that we have used many times to evaluate other devices. Additional hemodynamic testing will be performed on explanted valves, as will SEM and X-ray analysis.
用新型聚氨酯制成的新型心脏瓣膜

项目成果

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专利数量(0)

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PHILIP LITWAK其他文献

PHILIP LITWAK的其他文献

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{{ truncateString('PHILIP LITWAK', 18)}}的其他基金

Ambulatory ECMO System
动态 ECMO 系统
  • 批准号:
    6484355
  • 财政年份:
    2002
  • 资助金额:
    $ 4.99万
  • 项目类别:
High Efficiency Dialyzer Development
高效透析器开发
  • 批准号:
    6402952
  • 财政年份:
    2001
  • 资助金额:
    $ 4.99万
  • 项目类别:
Simplified Pump Oxygenator for Pediatric Use Phase II
儿科简易泵氧合器第二期
  • 批准号:
    6550618
  • 财政年份:
    2001
  • 资助金额:
    $ 4.99万
  • 项目类别:
Simplified Pump Oxygenator for Pediatric Use
儿童用简化泵式氧合器
  • 批准号:
    6337531
  • 财政年份:
    2001
  • 资助金额:
    $ 4.99万
  • 项目类别:
Active Mixing Membrane Oxygenator Phase II
主动混合膜充氧器二期
  • 批准号:
    6444256
  • 财政年份:
    1998
  • 资助金额:
    $ 4.99万
  • 项目类别:
PULSATILE PEDIATRIC BLOOD PUMP DEVELOPMENT
儿科脉动血泵开发
  • 批准号:
    2540819
  • 财政年份:
    1998
  • 资助金额:
    $ 4.99万
  • 项目类别:
ACTIVE MIXING MEMBRANE OXYGENATOR (AMMO)
主动混合膜制氧器 (AMMO)
  • 批准号:
    2715413
  • 财政年份:
    1998
  • 资助金额:
    $ 4.99万
  • 项目类别:
DEVELOPMENT OF A COMPLIANT HEMODIALYSIS ACCESS GRAFT
开发顺应性血液透析通路移植物
  • 批准号:
    3638535
  • 财政年份:
    1989
  • 资助金额:
    $ 4.99万
  • 项目类别:
PROCUREMENT OF PRIMARY REFERENCE MATERIALS
主要参考材料的采购
  • 批准号:
    3662025
  • 财政年份:
    1987
  • 资助金额:
    $ 4.99万
  • 项目类别:
DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT
高度顺应性血管移植物的开发
  • 批准号:
    3508462
  • 财政年份:
    1987
  • 资助金额:
    $ 4.99万
  • 项目类别:
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