THROMBORESISTANT POLYURETHANE CARDIAC VALVE DEVELOPMENT

新型聚氨基甲酸酯心瓣膜的研制 材料已经制作完成，并在体外进行了测试。这些 初步测试表明，该装置经久耐用(无故障 在持续至少2亿个循环的测试中)和拥有 血流动力学特征可与目前可用的相媲美 阀门。 为此用途开发的嵌段聚氨基甲酸乙酯是独一无二的 因为它的散装属性，对于长期的耐用性，和表面 特性，为了生物兼容性，已经被分开，并 由两种不同的材料发展而成。两者的交融 组件会产生一种结合了 每个对象的属性。这种材料的棒的体内评价和 脑室辅助装置泵囊已经证明了它 优良的物理性能和抗血栓特性。 我们建议制造瓣膜，并在体外和体外进行测试。 活着。稳态和脉动条件将用于 模拟循环测试。瓣膜将被植入左心室以 小牛的主动脉分流，我们多次使用这种模型来 评估其他设备。额外的血液动力学测试将是 对移植的瓣膜进行扫描电子显微镜和X射线分析。

A new cardiac valve fabricated from a novel polyurethane material has been fabricated and tested in vitro. These preliminary tests indicate that this device is durable (no failures in tests lasting at least 200 million cycles) and possesses hemodynamic characteristics comparable to currently available valves. The segmented polyurethaneurea developed for this use is unique because its bulk properties, for long-term durability, and surface properties, for biocompatibility, have been separated and developed in two distinct materials. Blending of the two components results in a single material incorporating the properties of each. In vivo evaluation of rods of this material and of ventricular assist device pumping sacs has demonstrated its excellent physical and thromboresistant characteristics. We propose to fabricate valves and test them both in vitro and in vivo. Steady-state and pulsatile conditions will be used for the mock loop testing. Valves will be implanted in left ventricle to aorta shunts in calves, a model that we have used many times to evaluate other devices. Additional hemodynamic testing will be performed on explanted valves, as will SEM and X-ray analysis.