DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT

一种新型的、高度顺应性的血管移植物，由一种独特的 将开发和测试聚亚安酯材料。体块和表面 这种材料所需的性能已被分离和开发 在两种不同的材料中独立存在。最终的聚合物将拥有 混合优化表面活性的整体优化特性 将共聚物化成优化的本体材料。 使用专利工艺制造多层管材，4 mm 直径的血管移植物将被生产出来。这些移植物将接受测试 无论是在体内还是体外。体外测试将包括顺应性、爆裂性 强度、结节半径、伸长率和缝线拔出强度。 体内评估将通过将8厘米长的假体植入 成年山羊的颈动脉。每隔一年将检查这些设备的通畅性 30天，使用99mTcm扫描。经过60天的观察， 移植物将被移植并重新注入体外试验方案。 此外，还将进行扫描电子显微镜和标准显微镜检查 已执行。

A new, highly compliant vascular graft fabricated from a unique polyurethane material will be developed and tested. The bulk and surface properties required of this material have been decoupled and developed independently in two separate materials. The final polymer will possess overall optimized characteristics by blending optimized surface active copolymers into the optimized bulk material. Using a patented process for fabrication of multi-layered tubing, 4 mm diameter vascular grafts will be produced. These grafts will be tested both in vivo and in vitro. In vitro testing will include compliance, burst strength, kink radius, elongation and suture pullout strength. In vivo evaluation will be accomplished by implanting 8 cm lengths in the carotid arteries of mature goats. These will be checked for patency every 30 days using 99m Technetium scanning. After 60 days of observation, grafts will be explanted and resubjected to the in vitro test protocol. Additionally, both SEM and standard microscopic examinations will be performed.