PULSATILE PEDIATRIC BLOOD PUMP DEVELOPMENT

描述（改编自申请人的摘要）：一个广泛认可的 小儿心脏手术的问题是缺乏合适的机械 循环支持设备。 在第一阶段计划中，一个财团 由Doppler Pulmonary Technologies，Inc. (CPT)，Nimbus，and the 匹兹堡大学（UOP）计划利用旋转泵技术， 专门用于新生儿/儿科（N/P）的血泵系统 使用. 该器械将能够产生脉动流， 在与N/P一致的持续时间内以不间断的方式运行 心切开术后应用（平均5-7天）。 第一阶段的设计活动将集中在清洗流体密封， 泵，电机/定子对，以及闭环，脉动 流量控制器 将制造足够的泵和控制器， 支持体外和体内测试。 关键的第一阶段示范 我们的N/P泵概念的可行性将是成功地执行三个 在体内羔羊研究为期七天的持续时间，其中基本 搏动性血液动力学性能、生物相容性和适用性 用于N/P应用的系统被记录。 拟议商业应用：不可用

DESCRIPTION (Adapted from applicant's abstract): A widely recognized problem in pediatric cardiac surgery is the lack of suitable mechanical circulatory support devices. In this Phase I program, a consortium consisting of CardioPulmonary Technologies, Inc. (CPT), Nimbus, and the University of Pittsburgh (UOP) plan to utilize rotary pump technology for a blood pump system specifically intended for neonatal/pediatric (N/P) use. This device will be capable of generating pulsatile flow and operating in an uninterrupted fashion for durations consistent with N/P postcardiotomy applications (5-7 days on average). Phase I design activities will focus on the purged fluid seal for the pump, the motor/stator pair, and the features for a closed-loop, pulsatile flow controller. Sufficient pumps and controllers will be fabricated to support in vitro and in vivo testing. The key Phase I demonstration of feasibility of our N/P pump concept will be to successfully perform three in vivo lamb studies for seven-day durations in which the basic hemodynamic performance, biocompatibility and suitability of the pulsatile system for N/P applications is documented. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE