DOPPLER ULTRASOUND BRAIN VELOCIMETRY MONITOR

多普勒超声脑速监测仪

• 批准号: 2714701
• 负责人: Mark A Moehring
• 金额: $ 10万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2714701
• 关键词: biomedical equipment development; cerebrovascular disorder diagnosis; clinical biomedical equipment; clinical research; diagnosis design /evaluation; heterodyning; human subject; intracranial hematoma; phantom model; ultrasound blood flow measurement

Intracranial hematoma from a slow venous bleed comprises a major cause of late death and disability in head trauma patients who initially appear asymptomatic. Hematoma detection is currently done by a CAT or MR scan, which is a costly and, in many hospitals, an inaccessible diagnostic modality. A need exists in clinical practice for a device to detect intracranial bleeding, that is less expensive and more widely available than CAT or MR imaging. This proposal is to develop a novel low- frequency, low PRF pulse Doppler ultrasound instrument to detect brain displacement overtime (brain velocimeter). Based on feasibility studies, the device will measure, in ten minutes, brain velocity at a series of positions between the temporal bones, the venue associated with 80% of intracranial hematomas. In Phase I, the best carrier frequency will be determined and a prototype velocimeter will be built and tested on a phantom model of intracranial hemorrhage, as well as a series of patients presenting with head trauma and referred for diagnostic CAT imaging. Phase II will include instrument redesign based on Phase I results and multi-center clinical trials. Phase II results will be used to design a Phase III device for the commercial market. PROPOSED COMMERCIAL APPLICATIONS: The instrument to be developed in this project, a brain velocimeter, will perform fast detection of very slow brain movement due to intracranial bleeding associated with head trauma. The instrument will not require an expert user and will target nurse and physician staff in the emergency medicine market. This simple to use low-tech ultrasound device will be aimed at a world wide market, especially where the current gold standard, CAT or MR imaging, is not affordable.

缓慢静脉出血引起的颅内血肿是主要原因。 首次出现的头部创伤患者的晚期死亡和残疾 没有任何症状。血肿检测目前由CAT或MR扫描完成， 这是一种昂贵的，而且在许多医院无法获得的诊断 情态。临床实践中需要一种设备来检测 颅内出血，这种方法更便宜，更容易获得 而不是CAT或MR成像。这项建议是为了开发一种新颖的低成本 频率、低重复频率脉冲多普勒超声仪对脑的检测 位移超时(脑速度计)。根据可行性研究， 该设备将在10分钟内以一系列 颞骨之间的位置，与80%的 颅内血肿。在第一阶段，最佳载频将是 确定的和原型的速度计将在一个 颅内出血的幻影模型，以及一系列的患者 表现为头部创伤，并转诊为诊断CAT成像。 第二阶段将包括根据第一阶段的结果重新设计仪器和 多中心临床试验。第二阶段的结果将被用来设计一个 第三阶段用于商业市场的设备。 建议的商业应用： 在这个项目中将要开发的仪器，大脑速度计，将 快速检测由于颅内原因导致的非常缓慢的脑运动 与头部创伤有关的出血。该仪器将不需要 专家用户，并将在紧急情况下针对护士和医生工作人员 医药市场。这种简单易用的低技术超声波设备将是 瞄准世界范围的市场，特别是在目前的金本位， CAT或MR成像，是负担不起的。