DOPPLER ULTRASOUND BRAIN VELOCIMETRY MONITOR

颅内血肿由缓慢静脉出血包括一个主要原因 在最初出现的头部创伤患者中， 无症状。血肿检测目前通过CAT或MR扫描完成， 这是一种昂贵的，在许多医院， 模态在临床实践中需要一种设备来检测 颅内出血，这是更便宜和更广泛的可用性 CT或MR成像。该项目旨在开发一种新型的低... 低频、低重频脉冲多普勒脑超声检测仪 位移随时间的变化（脑速度计）。根据可行性研究， 该设备将在10分钟内测量大脑的速度， 颞骨之间的位置，与80%的 颅内血肿在第一阶段，最佳载波频率为 确定和原型测速仪将建立和测试上的一个 颅内出血的体模，以及一系列患者 出现头部创伤并被转诊进行诊断性CAT成像。 第二阶段将包括根据第一阶段的结果重新设计仪器， 多中心临床试验。第二阶段的结果将用于设计一个 用于商业市场的III期器械。 拟议的商业应用： 在这个项目中开发的仪器，大脑速度计，将 执行由于颅内压引起的非常缓慢的大脑运动的快速检测 头部外伤导致的出血该仪器将不需要 专家用户，并将在紧急情况下针对护士和医生工作人员 医药市场。这种简单易用的低科技超声波设备将是 瞄准全球市场，特别是在目前的金本位制， CAT或MR成像，是负担不起的。

Intracranial hematoma from a slow venous bleed comprises a major cause of late death and disability in head trauma patients who initially appear asymptomatic. Hematoma detection is currently done by a CAT or MR scan, which is a costly and, in many hospitals, an inaccessible diagnostic modality. A need exists in clinical practice for a device to detect intracranial bleeding, that is less expensive and more widely available than CAT or MR imaging. This proposal is to develop a novel low- frequency, low PRF pulse Doppler ultrasound instrument to detect brain displacement overtime (brain velocimeter). Based on feasibility studies, the device will measure, in ten minutes, brain velocity at a series of positions between the temporal bones, the venue associated with 80% of intracranial hematomas. In Phase I, the best carrier frequency will be determined and a prototype velocimeter will be built and tested on a phantom model of intracranial hemorrhage, as well as a series of patients presenting with head trauma and referred for diagnostic CAT imaging. Phase II will include instrument redesign based on Phase I results and multi-center clinical trials. Phase II results will be used to design a Phase III device for the commercial market. PROPOSED COMMERCIAL APPLICATIONS: The instrument to be developed in this project, a brain velocimeter, will perform fast detection of very slow brain movement due to intracranial bleeding associated with head trauma. The instrument will not require an expert user and will target nurse and physician staff in the emergency medicine market. This simple to use low-tech ultrasound device will be aimed at a world wide market, especially where the current gold standard, CAT or MR imaging, is not affordable.