Doppler Ultrasound Automatic Mapping of Basal Cerebral Blood Flow

多普勒超声自动测绘基底脑血流

• 批准号: 6992643
• 负责人: Mark A Moehring
• 金额: $ 77.28万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6992643
• 关键词: brain circulation; brain disorder diagnosis; brain mapping; cerebral artery; clinical research; clinical trials; human subject; model design /development; patient oriented research; phantom model; stroke; technology /technique development; ultrasound blood flow measurement

DESCRIPTION (provided by applicant): This proposal is to develop new Doppler ultrasound technology for automatic diagnostic mapping of blood flow in the basal arteries of the brain. These vessels include the middle cerebral artery, the anterior cerebral artery, and the posterior communicating artery. This technology will enable transcranial Doppler diagnostic workup of the acute stroke patient for the rank-and-file emergency department physician, something not currently possible because of the expertise required to utilize transcranial Doppler in any setting. The Phase I SBIR work, from which this proposal moves forward, successfully demonstrated feasibility of the technology with particularly important demonstration of the fast signal processing algorithms for rapid location of flow signals in the angular territory viewable by the ultrasound beam. This technology is needed to quickly and simply provide diagnosis of pathological blood flow conditions that indicate acute stroke in progress, or the risk of stroke, as well as to selectively apply ultrasound to basal arteries of the brain during thrombolytic therapy for stroke. This technology also presents the potential for dramatically increasing the application to a much wider range of health professionals to obtain important diagnostic information with high sensitivity and specificity, and without the utilization frustrations experienced by current users both in locating and maintaining blood flow signals. The emergency department, the operating room, and the vascular laboratory all represent awaiting markets. Phase II targets significant enhancements to the technology demonstrated in Phase I, including increased angular viewing capability for mapping flow in multiple cerebral vessels. The work proposed will result in a prototype platform to explore a new ultrasound modality from which decisions can be made regarding production prototyping for each of the markets noted above. A device for automatic location of and fast mapping, tracking, and monitoring of blood flow in the basal arteries of the brain represents a major commercial market potential.

描述（由申请人提供）： 该提案旨在开发新的多普勒超声技术，用于脑基底动脉血流的自动诊断绘图。这些血管包括大脑中动脉、大脑前动脉和后交通动脉。这项技术将使普通急诊科医生能够对急性中风患者进行经颅多普勒诊断检查，这是目前不可能的，因为在任何情况下都需要使用经颅多普勒的专业知识。第一阶段SBIR工作，从该提案向前推进，成功地证明了该技术的可行性，特别是重要的快速信号处理算法的演示，用于在超声波束可见的角域中快速定位流量信号。需要该技术来快速且简单地提供指示正在进行的急性中风或中风风险的病理性血流状况的诊断，以及在中风的溶栓治疗期间选择性地将超声应用于脑的基底动脉。该技术还呈现了将应用显著增加到更广泛的健康专业人员的潜力，以获得具有高灵敏度和特异性的重要诊断信息，并且没有当前用户在定位和维持血流信号方面所经历的利用挫折。急诊室、手术室和血管实验室都是等待市场的地方。第二阶段的目标是对第一阶段中展示的技术进行重大改进，包括增加多个脑血管中映射流量的角度观察能力。拟议的工作将产生一个原型平台，以探索一种新的超声模式，从中可以做出关于上述每个市场的生产原型的决定。用于自动定位和快速映射、跟踪和监测脑基底动脉中的血流的设备代表了主要的商业市场潜力。