TCD Post-Resuscitation Blood Flow & Edema Monitor

TCD 复苏后血流量

• 批准号: 6934733
• 负责人: Mark A Moehring
• 金额: $ 14.98万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6934733
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; blood flow measurement; brain circulation; cardiopulmonary resuscitation; cerebral artery; cerebral ischemia /hypoxia; computer assisted diagnosis; computer data analysis; disease /disorder model; edema; heart arrest; human data; laser Doppler flowmetry; model design /development; myocardial ischemia /hypoxia; patient monitoring device; phantom model; stroke; swine

DESCRIPTION (provided by applicant): The aim of this project is to contribute a tool towards accomplishing improved outcomes following cardiopulmonary resuscitation (CPR). It is submitted in response to NIH program announcement PA-04-059. This proposal is to prototype an integrated Doppler ultrasound device to monitor brain blood flow and brain tissue motions in the post-resuscitation period following cardiac arrest. The technology proposed here promises high value for two considerations: (1) basic discovery of information for avoiding reperfusion injury in the post-resuscitation patient, and (2) development of a post-resuscitation monitor for commercial application, to reduce incidence of adverse outcomes currently experienced in the first thirty days following resuscitation. Power M-mode Doppler comprises the heart of this platform and is capable of monitoring four major vessels-the middle and anterior cerebral arteries, bilaterally-supplying 80% of the total blood flow to the brain, as well as perfusion related motions in the parenchyma in proximity to these vessels. The innovative core of this proposal is to combine in this platform the ability to acquire and store the following information for each of the monitored vessels in the post-resuscitation patient: blood velocity, relative blood volume flow, tissue motion dynamics (edema), and embolization. Instrument performance will be tested by phantom and then will be used to explore post-resuscitation physiology in an animal model of cardiac arrest. Our central hypothesis is that the Doppler ultrasound instrument we will construct will detect signals that correlate with known parameters indicating severity of injury in the post resuscitation period following cardiac arrest. Further, we anticipate this device will be more sensitive to the early stages of reperfusion injury that lead to acute adverse outcomes.

描述（由申请人提供）： 该项目的目的是提供一种工具，以改善心肺复苏 (CPR) 后的结果。它是为了响应 NIH 计划公告 PA-04-059 而提交的。该提案旨在构建集成多普勒超声设备的原型，以监测心脏骤停后复苏后的脑血流量和脑组织运动。这里提出的技术在两个方面具有很高的价值：（1）基本发现避免复苏后患者再灌注损伤的信息，以及（2）开发用于商业应用的复苏后监测器，以减少目前在复苏后前三十天内经历的不良后果的发生率。功率 M 型多普勒构成了该平台的核心，能够监测四个主要血管——大脑中动脉和大脑前动脉，两侧向大脑供应 80% 的总血流量，以及这些血管附近的实质中与灌注相关的运动。该提案的创新核心是在该平台中结合获取和存储复苏后患者中每条受监测血管的以下信息的能力：血流速度、相对血流量、组织运动动力学（水肿）和栓塞。仪器性能将通过体模进行测试，然后用于探索心脏骤停动物模型的复苏后生理学。我们的中心假设是，我们将构建的多普勒超声仪器将检测与已知参数相关的信号，这些参数表明心脏骤停后复苏后的损伤严重程度。此外，我们预计该设备将对导致急性不良后果的再灌注损伤的早期阶段更加敏感。