HARMONIC DOPPLER ULTRASOUND EMBOLUS CHARACTERIZATION

谐波多普勒超声栓塞表征

• 批准号: 6211168
• 负责人: Mark A Moehring
• 金额: $ 9.95万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6211168
• 关键词: air embolism; bioimaging /biomedical imaging; biomedical equipment development; embolism; phantom model; thromboembolism; ultrasound blood flow measurement

Recent Doppler ultrasound technological advances have demonstrated the unique capability to detect microemboli in the arterial and venous circulation. Microemboli have been implicated as the source or prelude of stroke and associated neurologic deficit. An unknown that would help determine the underlying pathology and the appropriate therapy is the composition of the individual microemboli. This proposal is to adapt advances in ultrasound echo processing, transducer, and harmonic detection technologies to determine microembolus composition as bubble or solid (formed element). Three areas of development are set forth: (1) adapting an existing digital Doppler platform to perform second harmonic Doppler analysis of echoes from microemboli, (2) developing a wide bandwidth ultrasound probe for normal Doppler processing at 1 MHz and second harmonic Doppler processing at 2 MHz, which have similar sensitivity patterns for each frequency, and (3) determine in vitro the best detection scheme for maximizing the ability to distinguish microbubbles from microparticles. This technology is especially important for reducing the incidence of stroke and neurologic compromise associated with various cardiovascular pathologies and surgery of the heart and of the carotid arteries. A device for discrimination of composition of microemboli represents a major commercial market potential. PROPOSED COMMERCIAL APPLICATIONS: The instrument to be developed in this project will characterize microemboli in blood flow as either gaseous or particulate, using ultrasound first and second harmonic Doppler analysis of microembolic signatures. This instrument will not require a user who is an ultrasound expert, and will target physician and technologist staff in the operating room, vascular laboratory, and emergency medicine markets. This simple to use ultrasound device will be aimed at a worldwide market.

最新的多普勒超声技术进步已经证明了在动脉和静脉循环中检测微栓子的独特能力。微栓子已被认为是中风和相关神经功能障碍的来源或前奏。有助于确定潜在病理和适当治疗的未知因素是单个微栓子的成分。这项建议是为了适应超声回声处理、换能器和谐波检测技术的进步，以确定微栓子的成分是气泡还是固体(形成的元素)。提出了三个方面的发展：(1)采用现有的数字多普勒平台对微栓子的回波进行二次谐波多普勒分析，(2)开发宽带超声探头，用于1 MHz的正常多普勒处理和2 MHz的二次谐波多普勒处理，每个频率具有相似的灵敏度模式，以及(3)在体外确定最大限度地区分微泡和微粒的能力的最佳检测方案。这项技术对于减少与各种心血管疾病以及心脏和颈动脉手术相关的中风和神经损害的发生率尤其重要。微栓子成分辨别装置代表着一个主要的商业市场潜力。建议的商业应用：本项目将开发的仪器将使用超声一次和二次谐波多普勒分析微栓子的信号，将血流中的微栓子表征为气态或颗粒状。该仪器将不需要是超声波专家的用户，并将目标对准手术室、血管实验室和急救药物市场的医生和技术人员。这款简单易用的超声波设备将瞄准全球市场。