ULTRASOUND ENHANCED THROMBOLYSIS AND MONITOR

超声增强溶栓和监测

• 批准号: 6141633
• 负责人: Mark A Moehring
• 金额: $ 9.97万
• 依托单位: SPENCER TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141633
• 关键词: brain circulation; digital imaging; fibrinolysis; fibrinolytic agents; laboratory rabbit; technology /technique development; ultrasound therapy

Research in recent years has shown that ultrasound can enhance clot lysis in the presence of thrombolytic agents such as t-PA or urokinase. The innovative aspect of this proposal is to explore these advances in an in vivo rabbit femoral artery model of the human middle cerebral artery to develop a noninvasive and cost effective method of thrombolysis monitoring and therapy in stroke. Advances in digital Doppler technology at Spencer Technologies enable a new dual approach to monitoring the degree of cerebral arterial recanalization while concurrently enhancing thrombolytic agent activity with ultrasound. Both of these activities-monitoring and therapy enhancement-can be done through the same transcranial ultrasound probe. The monitoring activity includes easy location of cerebral circulation using a digital Doppler color m-mode display, a format easily taught to medical professionals who are not Doppler ultrasound experts. Enhancing performance of thrombolytic agents with external ultrasound is anticipated to result in less thrombolytic agent required to accomplish restoration of blood flow to an infarcted region of the brain, and thereby decrease the incidence of hemorrhagic complication. This technology is important for reducing neurologic deficit associated with stroke and increasing the fraction of eligible patients who actually receive thrombolytic therapy. PROPOSED COMMERCIAL APPLICATIONS: This proposal comprises a platform for development of a Doppler ultrasound device which monitors cerebral blood flow velocity and concurrently enhances the thrombolytic effect of t-PA. The product produced will be specifically targeted at hospital emergency services. TCD is the only modality that exists for real time detection of cerebral blood flow during the early stages of stroke. No commercially available modality currently exists for enhancing thrombolytic therapy with ultrasound.

近年来的研究表明，在存在 t-PA 或尿激酶等溶栓剂的情况下，超声可以增强血栓溶解。该提案的创新之处是在人大脑中动脉的体内兔股动脉模型中探索这些进展，以开发一种无创且具有成本效益的中风溶栓监测和治疗方法。 Spencer Technologies 数字多普勒技术的进步实现了一种新的双重方法来监测脑动脉再通程度，同时通过超声增强溶栓剂活性。这两项活动（监测和治疗增强）都可以通过同一个经颅超声探头来完成。监测活动包括使用数字多普勒彩色 m 模式显示器轻松定位脑循环，这种格式很容易向非多普勒超声专家的医疗专业人员教授。通过外部超声增强溶栓剂的性能预计将减少完成脑梗死区域血流恢复所需的溶栓剂，从而降低出血并发症的发生率。这项技术对于减少与中风相关的神经功能缺损和增加实际接受溶栓治疗的合格患者比例非常重要。拟议的商业应用：该提案包括开发多普勒超声设备的平台，该设备可监测脑血流速度，同时增强 t-PA 的溶栓效果。生产的产品将专门针对医院紧急服务。 TCD 是唯一可以实时检测中风早期阶段脑血流量的方法。目前尚不存在用于增强超声波溶栓治疗的市售方式。