TISSUE PERFUSION AND BLOOD FLOW MONITORING TECHNOLOGY

毛细血管血流量的评估对于许多医学应用是重要的。 程序和条件。两种光学相干技术，激光多普勒 速度计和动态激光散斑，已被应用于测量血液 流速 激光散斑对比度分析方法 先进的数码摄影的优势，以扩展传统的 激光散斑方法的非扫描，全场技术。相位 我的目标是开发一种激光散斑振幅成像技术， 监测毛细血管血流速度，并证明准确性 该技术等于或优于激光多普勒测速技术。 该项目的目标是开发一种低成本的定量装置， 监测组织灌注。第一阶段侧重于可行性 演示提供皮肤血流的定量数据， 动物模型第二阶段将开发一个原型， 临床研究所提出的技术的优点是更快， 更广的区域覆盖、更简单、非接触和更好的再现性。 拟议的商业应用： 光学装置将提供对组织的简单和非接触式监测 整形和重建期间和之后患者的生存能力 涉及皮瓣和手指再附着的手术，以及创伤期间 治疗程序。商业应用包括诊断 烧伤患者的状况，糖尿病患者的四肢，以及 用于血管密度增加的患者，如皮肤癌。

The assessment of capillary blood flow is important for many medical procedures and conditions. Two optical coherent techniques, laser Doppler velocimetry and dynamic laser speckle, have been applied to measure blood flow velocities. The Laser Speckle Contrast Analysis method takes advantage of the advanced digital photography to extend the conventional laser speckle method to a nonscanning, full-field technique. The Phase I aim is to develop a laser speckle amplitude mapping technology for monitoring capillary blood flow velocity and demonstrate the accuracy of the technology at or better than that of the laser Doppler velocimetry. The goal of the project is to develop a low-cost device for quantitative monitoring of tissue perfusion. Phase I focuses on the feasibility demonstration to provide quantitative data on skin blood flow using animal models. A prototype will be developed in Phase II to use in a clinical study. The advantages of the proposed technique are faster, wider area coverage, simpler, noncontact, and better reproducibility. PROPOSED COMMERCIAL APPLICATIONS: The optical device will provide easy and noncontact monitoring of tissue viability for patients during and after plastic and reconstructive surgery involving flaps and digit reattachment, and during trauma treatment procedures. Commercial application includes diagnosing the conditions of burn patients, the extremities of diabetic patients, and for patients with increased vascular density such as skin cancer.