OPTICAL MONITORING OF BREAST TISSUE PERFUSION

乳腺组织灌注的光学监测

• 批准号: 6142530
• 负责人: Leonard William WINCHESTER
• 金额: $ 10万
• 依托单位: CW OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142530
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; blood flow measurement; breast neoplasm /cancer diagnosis; breast neoplasms; diagnosis design /evaluation; digital imaging; heterodyning; lasers; perfusion

Breast cancer is a leading cause of death for women in the United States, and an estimated 43,300 women will die of breast cancer in 1999. As tumors grow, an extensive vasculature is formed. Recent measurements have shown a clear correlation between high local blood flow and the existence of breast tumors. This project proposes the innovative use of an optical imaging technique for real-time perfusion monitoring of breast tissues. Detection of changes in the vascular structure of breasts using optical methods offers a means for regular, noninvasive, and sac monitoring of patients and for early detection of tumors. The hypothesis of this research is that the proposed technique can be used to identity regions of high cutaneous blood flow due to increased vascularity associated with malignant breast tumors. The objective is to establish the feasibility of the technique for breast cancer detection. Specific aims of Phase I include developing a prototype, evaluating the prototype, establishing baselines and accuracy of the method, and investigating critical engineering milestones for Phase II. PROPOSED COMMERCIAL APPLICATIONS: The proposed technique will provide a useful tool for breast tumor screening. The optical imaging device is economical and portable and can be used by primary care physicians and gynecologists. The component cost of a commercial device is estimated to be less than $1,200. This device can be used with mammography and may reduce the requirements for repeated x-ray exposures.

乳腺癌是美国妇女死亡的主要原因，估计1999年将有43，300名妇女死于乳腺癌。随着肿瘤的生长，形成了广泛的脉管系统。最近的测量结果表明，高局部血流和乳腺肿瘤的存在之间存在明显的相关性。该项目提出了创新的使用光学成像技术的实时灌注监测乳腺组织。使用光学方法检测乳房血管结构的变化提供了一种对患者进行定期、无创和囊状监测以及早期检测肿瘤的方法。这项研究的假设是，所提出的技术可用于识别由于与恶性乳腺肿瘤相关的血管增加而导致的高皮肤血流量区域。其目的是建立乳腺癌检测技术的可行性。第一阶段的具体目标包括开发原型，评估原型，建立基线和方法的准确性，并调查第二阶段的关键工程里程碑。拟议的商业应用：拟议的技术将提供一个有用的工具，乳腺肿瘤筛查。该光学成像装置经济且便携，可由初级保健医师和妇科医师使用。商业设备的组件成本估计不到1，200美元。该设备可与乳房X线摄影一起使用，并可减少重复X线曝光的要求。