Optical Imaging of Retinal Blood Circulation

视网膜血液循环的光学成像

• 批准号: 6951458
• 负责人: Leonard William WINCHESTER
• 金额: $ 38.51万
• 依托单位: CW OPTICS, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951458
• 关键词: bioengineering /biomedical engineering; bioimaging /biomedical imaging; blood flow measurement; clinical research; diagnosis design /evaluation; hemodynamics; human subject; image processing; noninvasive diagnosis; ophthalmoscopy; optics; retina circulation; retina circulation disorder

The evaluation of retinal hemodynamics is an import diagnostic subject and has been one of the most difficult challenges in ophthalmology. The retina provides direct optical access to both the central nervous system and afferent and efferent central nervous system vasculature. This unique feature has provided generations of ophthalmologists with the ability to evaluate multi-system diseases without invasive diagnostic testing, using direct and indirect ophthalmoscopy, and slit lamp biomicroscope examination. These techniques, however, cannot directly quantify retinal blood velocity, nor do they detect preclinical alterations predictive of eventual significant morbidity. The trend toward preventive medicine prescribes a more sensitive technique to reliably quantify subtle changes in retinal hemodynamics. The main objective of this Phase II project is to test the feasibility of the proposed imaging technique for the measurement of human retinal velocities. Specific aims of Phase II include (1) to develop an advanced prototype, (2) to improve algorithms, (3) to conduct clinical research, (4) to investigate accuracy and utility, and (5) to examine commercial application issues. The proposed imaging method employs spatial averaging of the dynamic events, only one image is needed for blood velocity calculations. It allows acquiring of full-field retinal images in near realtime. The short exposure time reduces the effects of motion artifacts. This new technology has the potential to improve ocular management of patients. The speckle imager can be incorporated in a fundus camera at a fraction of the cost of a laser Doppler device. A noninvasive, realtime retinal imager allows the physicians to record and keep track of patients' retinal hemodynamics to detect early signs of ocular disorders.

视网膜血流动力学的评估是一项重要的诊断课题，也是眼科最困难的挑战之一。视网膜为中枢神经系统以及传入和传出中枢神经系统的血管系统提供了直接的光学通路。这一独特的功能使几代眼科医生能够在不进行侵入性诊断测试的情况下，使用直接和间接眼底镜检查以及裂隙灯生物显微镜检查来评估多系统疾病。然而，这些技术不能直接量化视网膜血流速度，也不能检测到临床前的变化，预测最终的显著发病率。预防医学的趋势为可靠地量化视网膜血流动力学的细微变化开出了一种更敏感的技术。这一第二阶段项目的主要目标是测试所提出的成像技术用于测量人体视网膜速度的可行性。第二阶段的具体目标包括(1)开发先进的原型，(2)改进算法，(3)进行临床研究，(4)调查准确性和实用性，以及(5)检查商业应用问题。该成像方法采用动态事件的空间平均，只需要一幅图像就可以计算血流速度。它可以近乎实时地获取全视野视网膜图像。较短的曝光时间会减少运动伪影的影响。这项新技术有可能改善患者的眼睛管理。散斑成像仪可以安装在眼底相机中，成本只有激光多普勒设备的一小部分。一种非侵入性的实时视网膜成像仪允许医生记录和跟踪患者的视网膜血流动力学，以检测眼部疾病的早期迹象。